Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2)
Cofactors used
What it does, reaction by reaction
Glycerol-3-Phosphate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Glycerol-3-phosphate + FAD -> dihydroxyacetone phosphate + FADH2
Converts Glycerol-3-phosphate FAD into Dihydroxyacetone phosphate FADH2
› Notes
Faces the intermembrane space and feeds electrons to the Q pool, so each cytosolic NADH yields only ~1.5 ATP. Dominant in skeletal muscle and brown adipose tissue.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.
Yuan L, Wang T, Song Y, Guo P, Zhu Y, Cao Y, Song B, Yu Z. · 2026-06-25
open access unreviewed -
2
Differential expression of mitomiRs in pancreatic islet cells associated with maternal protein restriction.
Jacovetti C, Regazzi R. · 2026-01-01
open access unreviewed -
3
Multi-omics analyses prioritize potential biomarkers and drug targets for obstructive sleep apnea.
Chen Z, Jian S, Ouyang H, Wu Y, Lv L, Yi M, Zhang Y. · 2026-10-01
unreviewed -
4
Aglycemia triggers alternative electron transport to sustain mesenchymal stem cell survival under anoxia.
Refeyton A, Amoedo ND, Labat V, Vignane T, Buré C, Pinson B, Ley-Ngardigal S, Debeissat C, Bursac B, Claverol… · 2026-07-14
open access unreviewed -
5
Interferon gamma and inflammatory response genes by weighted gene co-expression network analysis reveal significant associations with severe dengue infection in India
Shamim U, Arora S, Maurya R, Soni J, Shukla R, Mehta P, Tarai B, Budhiraja S, Pandey R. · 2026-09-23
open access unreviewed -
6
Urban Tree Pathogens: The Impact of Neofusicoccum luteum on Araucaria heterophylla (Norfolk Island Pine).
Petrova A, Pratt C, Bar I, T Sambasivam P, Michael RN. · 2026-09-28
open access unreviewed -
7
Integrating Multi-Omics and Machine Learning to Predict Microplastic Cytotoxicity Under Leave-One-Polymer-Out Validation.
Fu Y, Liu C, Chen S, Zhang K, Yuan B, Zhang H. · 2026-09-24
unreviewed -
8
Adipocyte <i>Gata3</i> Is a Diet-Inducible Driver of Pathological Adipose Remodeling and Systemic Metabolic Disease.
Qin M, Li F, Yang M, Wang L, Sharifi BG, Shah PK. · 2026-09-10
open access unreviewed -
9
Mitochondrial Function-Related Genes in Sleep Disorders: A Multi-Omics Mendelian Randomization Study.
Xu J, Zhang Z, Yu L, Feng Y. · 2026-09-12
open access unreviewed -
10
CaMKIIβ Signaling drives expression of metabolic and stress response genes in skeletal muscle, and its loss contributes to the LGMDR1 phenotype.
Kramerova I, Anastopulos F, Becerra D, Goldstein de Salazar R, Keeble AR, Chamberlain JS, Moore SA, McNally E… · 2026-09-01
open access unreviewed
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