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unreviewed

Methionine adenosyltransferase (MAT)

1 reactions · 1 pathways

Cofactors used

ATP Pi PPi SAM

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 1 Irreversible

L-methionine + ATP → S-adenosylmethionine (SAM) + Pᵢ + PPᵢ

Converts Methionine ATP into S-adenosylmethionine (SAM) Pi PPi

› Notes

Methionine adenosyltransferase (MAT; MAT I/III in adult liver, MAT II extrahepatically) transfers the adenosyl moiety of ATP to methionine. ATP is cleaved to tripolyphosphate equivalents (Pᵢ + PPᵢ, with PPᵢ hydrolysis driving the reaction); this is an essentially irreversible activation step that consumes three high-energy phosphate bonds.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Accelerated by

Methionine availability; demand for SAM

Inhibited by

Product/SAM accumulation; oxidative or liver injury can impair isoenzyme activity

Hormonal control

Insulin, glucagon, and nutritional state alter hepatic MAT expression indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment.

    Lin H, Deng X, Yang Y, Zhang R, Wang YD, Chen WD. · 2026-08-18

    open access unreviewed
  2. 2
    Chromatin dynamics and cellular energy homeostasis.

    Suganuma T, Workman JL. · 2026-10-01

    open access unreviewed
  3. 3
    Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.

    Fustin JM. · 2026-10-01

    open access unreviewed
  4. 4
    S-Adenosylmethionine-Dependent Methylation, Protein Arginine Methyltransferases and Cardiovascular Diseases.

    Yan Z, Zhao W, Zhao N, Li J. · 2026-09-19

    open access unreviewed
  5. 5
    Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential.

    Radosavljevic T, Djuretic J, Brankovic M, Samardzic J, Curuvija I, Vucevic D. · 2026-09-20

    open access unreviewed
  6. 6
    Supplementation of Rumen-Protected Methionine to Heat-Stressed Transition Cows Impacts Mammary Gland Cell Dynamics and Gene Expression.

    Davidson BD, Guenther MC, Duclos JE, Sfulcini M, Sherlock DN, Boutinaud M, Laporta J. · 2026-09-03

    open access unreviewed
  7. 7
    Maternal methionine supplementation regulates skeletal muscle development through N<sup>6</sup>-methyladenosine mRNA methylation in broiler offspring.

    Gao M, Chen S, Chen Y, Han Q, Li D, Li W, Li X, Liu A, Nie W, Guo Y, Lv Z. · 2026-05-04

    open access unreviewed
  8. 8
    Rational design for improved thermostability of methionine adenosyltransferase based on FoldX, Rosetta, and multidimensional virtual screening.

    Yang Y, Ma H, Wang D, Jiang Z, Wang X, Zhao Y, Li R, Xu C. · 2026-05-27

    unreviewed
  9. 9
    Food-dependent activation of one-carbon metabolism during heat shock in Mytilus californianus.

    Fabela RF, May MA, Tomanek L. · 2026-08-11

    open access unreviewed
  10. 10
    PRMT1-Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis.

    Wang H, Zhang M, Gong W, Wu J, Zhang J, Zhang W, Liu Y, Wang K, Huang C, Zhou J, Wu S, Li Y, Li T. · 2026-06-01

    cited 1× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.