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unreviewed

Methionine adenosyltransferase (MAT)

1 reactions · 1 pathways

Cofactors used

ATP Pi PPi SAM

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 1 Irreversible

L-methionine + ATP → S-adenosylmethionine (SAM) + Pᵢ + PPᵢ

Converts Methionine ATP into S-adenosylmethionine (SAM) Pi PPi

› Notes

Methionine adenosyltransferase (MAT; MAT I/III in adult liver, MAT II extrahepatically) transfers the adenosyl moiety of ATP to methionine. ATP is cleaved to tripolyphosphate equivalents (Pᵢ + PPᵢ, with PPᵢ hydrolysis driving the reaction); this is an essentially irreversible activation step that consumes three high-energy phosphate bonds.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Accelerated by

Methionine availability; demand for SAM

Inhibited by

Product/SAM accumulation; oxidative or liver injury can impair isoenzyme activity

Hormonal control

Insulin, glucagon, and nutritional state alter hepatic MAT expression indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Maternal methionine supplementation regulates skeletal muscle development through N<sup>6</sup>-methyladenosine mRNA methylation in broiler offspring.

    Gao M, Chen S, Chen Y, Han Q, Li D, Li W, Li X, Liu A, Nie W, Guo Y, Lv Z. · 2026-05-04

    open access unreviewed
  2. 2
    Rational design for improved thermostability of methionine adenosyltransferase based on FoldX, Rosetta, and multidimensional virtual screening.

    Yang Y, Ma H, Wang D, Jiang Z, Wang X, Zhao Y, Li R, Xu C. · 2026-05-27

    unreviewed
  3. 3
    The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis

    Basak S, Gomez D. · 2026-06-01

    open access unreviewed
  4. 4
    Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9.

    Hintzen JCJ, Yu Z, Ahmad S, Zhang X, Zhao YY, Deng H, Schütz L, Ram M, Kaminska JZ, Drozak J, Weinhold E, Guo… · 2026-06-01

    open access unreviewed
  5. 5
    One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.

    Al Qassab M, Bou Ghanem A, Hussayni Y, Kadbey R, Ratel Y, Yehya S, Zahr M, Ghadieh HE, Abi Khattar Z, Azar S,… · 2026-03-17

    open access unreviewed
  6. 6
    Methionine restriction and mimetics to ameliorate human aging and disease.

    Parkhitko AA, Pathak S, Johnson JE, Mittendorfer B, Steinhauser ML. · 2025-10-06

    cited 5× unreviewed
  7. 7
    Engineering <i>Escherichia coli</i> for Ergothioneine Production via Metabolic Engineering and Fermentation Optimization.

    Liu Y, Wen Y, Hu R, Han R, Liu D, Zhang H. · 2026-05-11

    open access unreviewed
  8. 8
    Lipid Remodeling in Mouse SR-B1-Deficient Embryos with Oxidative Stress-Associated Neural Tube Defects.

    Quiroz A, Santander N, Nicolás GDE, Leung KY, Busso D. · 2026-05-16

    open access unreviewed
  9. 9
    Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury.

    Zhu S, Zhong S, Lin X, Zhao C, Li Y. · 2026-05-01

    open access unreviewed
  10. 10
    A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF.

    Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T. · 2026-05-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.