unreviewed
Methenyl-THF cyclohydrolase (MTHFD1)
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
step 4
Reversible
5,10-Methenyl-THF + H₂O ⇌ 10-formyl-THF
Converts 5,10-Methenyl-THF H2O into 10-Formyl-THF
› Notes
The cyclohydrolase activity of MTHFD1 (or mitochondrial MTHFD enzymes) converts the methenyl to the formyl oxidation state. This reversible hydration supplies 10-formyl-THF for purine biosynthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.