Lactate dehydrogenase (LDHB) + gluconeogenic enzymes
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Cori Cycle (lactate shuttle) Carbohydrate Metabolism · Cytosol (muscle) + liver
Lactate -> pyruvate -> glucose (liver, 6 ATP equivalents)
Converts Lactate into Pyruvate
› Notes
Net cost of 4 ATP equivalents per cycle, shifting the energy burden to liver. Metformin-associated and hypoxic lactic acidosis reflect failure of this arm.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
<i>Helicobacter pylori</i> activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis.
Chen H, Wang Y, Wang Z, Su W, Shao Y, Zhang G, Wang Z, Ge Y, Zhou X. · 2026-04-22
open access unreviewed -
2
Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications.
Chinopoulos C. · 2026-05-16
open access unreviewed -
3
Ligilactobacillus salivarius 8-2 attenuates intestinal mucosal injury in chicks via the mitochondrial fision-glycometabolism reprogramming axis.
Hua Y, Zou M, Zhang L, Chen L, Rao X, Wei G, Wei J, Wei M, Wei Y, Li J. · 2026-04-17
open access unreviewed -
4
Molecular Effects of Parkia speciosa Hassk. Empty Pod Extract in Colon Cancer: A Transcriptomic and Proteomic Perspective
Chaiwichien A, Osotprasit S, Samrit T, Smith S, Suwansa-Ard S, Cummins S, Kueakhai P, Changklungmoa N. · 2026-06-01
open access unreviewed -
5
High-Intensity Interval Training Attenuates Hepatic Fibrosis by Remodeling Lactate Metabolism in MASLD.
Chen X, Su J, Huang W, Li Y, Zhang J. · 2026-06-13
open access unreviewed -
6
Energy substrate preference and metabolic flexibility in quiescent and oxytocin-stimulated human myometrial cells.
Prifti KK, Dave RM, Mitchum KT, Rich JL, Gill RM, Mbadhi MN, Frolova AI. · 2026-06-09
open access unreviewed -
7
Integrated three-dimensional genomic analysis reveals that dynamic changes in chromatin structure are associated with differences in egg production performance between White Leghorn and Wenchang chickens.
Wang S, Cao Y, Tian GG. · 2026-06-10
open access unreviewed -
8
Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics.
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S. · 2026-06-01
open access unreviewed -
9
A Novel Approach to Neuropathic Pain Treatment: Lactylation Targeting Microglia.
Chen M, Yang F, Sun Y, Feng S. · 2026-06-11
open access unreviewed -
10
Metabolic reprogramming in fibrosis-related diseases: underlying mechanisms and therapeutics.
Feng Y, Zhang X, Wang XJ, Chen C. · 2026-06-05
cited 1× open access unreviewed
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