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rate-limiting unreviewed

Isocitrate dehydrogenase (mitochondrial NAD+-dependent IDH3)

1 reactions · 1 pathways

Cofactors used

Mg2+ · Magnesium Mn2+ NAD+ · B3 (Niacin) NADH · B3 (Niacin)

Clinical / pharmacological. Rate-limiting TCA step; IDH1/2 neomorphic mutations produce 2-hydroxyglutarate in glioma/AML

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 3 Irreversible rate-limiting

Isocitrate + NAD+ → oxalosuccinate + NADH + H+; oxalosuccinate → alpha-ketoglutarate + CO2

Converts Isocitrate NAD+ into Oxalosuccinate NADH H+

› Notes

Required cofactors: NAD+ and Mg2+ or Mn2+. This is an essentially irreversible, rate-limiting regulatory step of the cycle; the CO2 released in the first turn is not necessarily derived from the newly introduced acetyl carbons.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Citric Acid Cycle (TCA / Krebs Cycle)

Listed there as: Isocitrate dehydrogenase (IDH3)

Accelerated by

ADP, Ca2+ in muscle

Inhibited by

ATP, NADH

Hormonal control

Ca2+ released during contraction activates IDH3; hormonal effects are largely indirect through energy demand and substrate supply

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Bioinspired 0D mitochondrial bioenergetic actuators rewire cartilage progenitor cell metabolism for osteoarthritis remission.

    Lin W, Chen Z, Liu W, Wang X, Song W, He A, Mao Y, Guo H, Jiang Z, Zhou C, Yu Y, Liu W. · 2026-07-01

    open access unreviewed
  2. 2
    Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer’s disease neurons

    · 2026-10-01

    open access unreviewed
  3. 3
    Fenitrothion induces sex-specific glucose metabolism dysregulation in rats by targeting PK/glycolysis in males and IDH3/TCA cycle in females.

    Guo Y, Gu D, Okeke ES, Feng W, Chen Y, Mao G, Yang L, Zhao T, Wu X. · 2026-06-13

    unreviewed
  4. 4
    Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming

    · 2026-09-23

    open access unreviewed
  5. 5
    Multi-Pathway Antifungal Mechanism of Marine-Derived <i>Bacillus</i> sp. BAF143 Against <i>Aspergillus flavus</i>.

    Ou X, Li Y, Wang S, Wang Q, Huang S, Yu F, Luo Y, Liang M, Yang L, Pan L, Wang X, Yang D. · 2026-09-17

    open access unreviewed
  6. 6
    Integrated Metabolomic and Proteomic Analyses Reveal Differential Regulation of the Citrate Cycle and Pentose Phosphate Pathway by <i>Cannabis sativa</i> Extract and the Synthetic Cannabinoid HU210 in GT1-7 Neuronal Cells: Sequential Extraction of Metabolites and Proteins from a Single Cell Pellet.

    Natori Y, Mizuno D, Doshi M, Kawahara M, Ishii A. · 2026-09-03

    open access unreviewed
  7. 7
    Methods for assessing binding of a small-molecule radioligand to soluble enzyme isocitrate dehydrogenase 1 variants.

    Deuther-Conrad W, Lai TH, Maurer A, Wenzel B. · 2026-09-22

    open access unreviewed
  8. 8
    Tuning epigenetics to enhance cancer virotherapy.

    Wang Y, Zhang L, Che Y, Yang F, Sun ZJ. · 2026-06-26

    open access unreviewed
  9. 9
    IDH3 regulates citrate homeostasis to control metabolic fitness and venetoclax resistance of AML stem cells.

    Demir A, Mönnig M, Aroua N, Besiridou E, Schmidt V, Müller K, Renders S, Schulte F, Pouya A, Waclawiczek A, L… · 2026-09-17

    unreviewed
  10. 10
    MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease.

    Becker A, Eichmann TO, Vasiliev V, Mey KA, Petzsch P, Rossi A, Distelmaier F, Anand R. · 2026-09-15

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.