Isocitrate dehydrogenase (mitochondrial NAD+-dependent IDH3)
Cofactors used
Clinical / pharmacological. Rate-limiting TCA step; IDH1/2 neomorphic mutations produce 2-hydroxyglutarate in glioma/AML
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Isocitrate + NAD+ → oxalosuccinate + NADH + H+; oxalosuccinate → alpha-ketoglutarate + CO2
Converts Isocitrate NAD+ into Oxalosuccinate NADH H+
› Notes
Required cofactors: NAD+ and Mg2+ or Mn2+. This is an essentially irreversible, rate-limiting regulatory step of the cycle; the CO2 released in the first turn is not necessarily derived from the newly introduced acetyl carbons.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Citric Acid Cycle (TCA / Krebs Cycle)
Listed there as: Isocitrate dehydrogenase (IDH3)
ADP, Ca2+ in muscle
ATP, NADH
Ca2+ released during contraction activates IDH3; hormonal effects are largely indirect through energy demand and substrate supply
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Aberrant protein S-nitrosylation disrupts axonal development and metabolic homeostasis in a Cntnap2 mouse model of autism.
Kartawy M, Ojha SK, Nimgampalle M, Amal H. · 2026-05-28
open access unreviewed -
2
2-Oxocarboxylic acid metabolic pathway fuels mitochondrial ATP synthesis to power oviposition in Bactrocera dorsalis.
Ye L, Zhang Q, Yang J, Cheng D. · 2026-03-07
unreviewed -
3
Metabolic support of trained immune responses in myeloid cells.
Jarit-Cabanillas A, Dunphy G, Virga F, Van den Bossche J, Sancho D. · 2026-06-19
open access unreviewed -
4
Fenitrothion induces sex-specific glucose metabolism dysregulation in rats by targeting PK/glycolysis in males and IDH3/TCA cycle in females.
Guo Y, Gu D, Okeke ES, Feng W, Chen Y, Mao G, Yang L, Zhao T, Wu X. · 2026-06-13
unreviewed -
5
Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.
Huang CW, Wen CY, Tsai AP, Wang B, Tsui KH, Hsu YJ, Li CJ. · 2026-06-01
open access unreviewed -
6
Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.
Terra C, Terrier O, Le Gouellec A. · 2026-06-02
open access unreviewed -
7
Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus.
Kong L, Tan H, Zhu X, Wen Y, Li Y. · 2026-02-19
open access unreviewed -
8
Nitric oxide generates a coordinated histone modification signature consistent with chromatin compaction, linked to methyl-modifying enzyme dysregulation and tumor-permissive gene silencing.
Shayan S, Vasudevan D, Thomas DD. · 2026-04-15
open access unreviewed -
9
Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis.
Liu H, Zhao S, Gao H, Wang Y, Gao J, Guo P, Yang Y, Cui W, Zhang S, Shi Y, Xie G, Han Y, Zhou J, Zhang Q, Zou… · 2026-03-16
open access unreviewed -
10
Proteomic analysis of spermathecal fluid in Amphioctopus fangsiao: molecular insights into long-term sperm storage.
Yao J, Sun X, Huang Z, Li Y, Luo Q, Wang W, Sun G, Xu X, Li Z, Li B, Cui C, Wang Q, Yang J, Feng Y. · 2026-01-23
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.