What it does, reaction by reaction
Purine Salvage Pathway Nucleotide Metabolism · Cytosol
Hypoxanthine → IMP
Converts Hypoxanthine into IMP
› Notes
HGPRT catalyzes hypoxanthine + PRPP → IMP + PPi. Mg2+ supports phosphoribosyl transfer, and PPi hydrolysis drives the reaction forward. This is effectively irreversible in vivo and salvages hypoxanthine directly to the central purine intermediate.
Guanine → GMP
› Notes
HGPRT catalyzes guanine + PRPP → GMP + PPi. This is also effectively irreversible in vivo; the same enzyme therefore salvages both hypoxanthine and guanine.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.
Noroozzadeh M, Changaei M, Farhadi-Azar M, Mousavi M, Mousapour P, Amiri M, Jorjani M, Ramezani Tehrani F. · 2026-08-31
open access unreviewed -
2
Genetically engineered hypoimmunogenic iPSCs: Strategies and considerations for clinical applications.
Choi JKM, Hotta A. · 2026-09-19
open access unreviewed -
3
Elevated miR-103b in exosomes derived from brain-metastatic triple-negative breast cancer cells remodels the brain pre-metastatic niche (PMN).
Zhou L, Ke J, Zhang S, Xiao S, Zhang H, Liu S, Liu L, Liu M, Lu Z, Zheng S. · 2026-09-25
open access unreviewed -
4
A homozygous lamin B receptor variant resulting in Pelger-Huët anomaly without skeletal dysplasia.
Hoffmann K, Vayá A, Ricart Vayá JM, Küchler O, Schmidt A, von Kügelgen N, Fischer-Zirnsak B, Sperling K. · 2026-08-20
open access unreviewed -
5
HLA-G functions as a tumor-intrinsic driver of growth and survival in renal cell carcinoma.
Ajith A, Jayaprasad AG, Chang U, Sreekumar A, Lin M, Bravo-Egana V, Mulloy LL, Horuzsko DD, Carosella ED, Hor… · 2026-08-13
open access unreviewed -
6
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice.
Connell E, Le Gall G, McArthur S, Lang L, Breeze B, Liaquat M, Pontifex MG, Sami S, Pourtau L, Gaudout D, Mül… · 2026-01-13
cited 5× open access unreviewed -
7
Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder.
Costello A, Linning-Duffy K, Shi J, Lonstein JS, Yan L. · 2026-01-08
cited 3× open access unreviewed -
8
ER proteostasis failure in HYOU1 deficiency alters B cells, neutrophils, and interferon signalling.
Idani A, Bibi-Triki S, Stemmelen T, Radosavljevic M, Grenot P, Hirschler A, Bernard A, Rosenzwajg M, Yang J, … · 2026-09-07
open access unreviewed -
9
6 weeks of fartlek-style endurance training does not alter physiological responses to mild cold exposure but attenuates the cold-induced plasma noradrenaline response: A randomized, matched control trial.
Braunsperger A, Becker L, Camargo DP, Radsak S, Paintner M, Kossenakis D, Song X, Kraus A, Birnkammer A, Mesm… · 2026-08-25
open access unreviewed -
10
Modulating hepatic hypoxanthine metabolism relieve metabolic stress-related neurovascular resilience disturbance via the liver-brain axis.
Tu H, Hou Y, Cui W, Wang X, Chen M, Shi M, Kang T, Jiang Y, Wu Q, Li W, Cai J, Wang L, Wang Z, Hou B, Chang L… · 2026-07-15
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.