What it does, reaction by reaction
Purine Salvage Pathway Nucleotide Metabolism · Cytosol
Hypoxanthine → IMP
Converts Hypoxanthine into IMP
› Notes
HGPRT catalyzes hypoxanthine + PRPP → IMP + PPi. Mg2+ supports phosphoribosyl transfer, and PPi hydrolysis drives the reaction forward. This is effectively irreversible in vivo and salvages hypoxanthine directly to the central purine intermediate.
Guanine → GMP
› Notes
HGPRT catalyzes guanine + PRPP → GMP + PPi. This is also effectively irreversible in vivo; the same enzyme therefore salvages both hypoxanthine and guanine.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice.
Connell E, Le Gall G, McArthur S, Lang L, Breeze B, Liaquat M, Pontifex MG, Sami S, Pourtau L, Gaudout D, Mül… · 2026-01-13
cited 1× open access unreviewed -
2
Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder.
Costello A, Linning-Duffy K, Shi J, Lonstein JS, Yan L. · 2026-01-08
cited 1× open access unreviewed -
3
EIF3B promotes oral squamous cell carcinoma progression via the PI3K/AKT pathway and is negatively regulated by miR-124-3p.
Zheng X, Gao B, Li J, Ji Y, Lin Y, Lin L, Qiu Y. · 2026-06-16
unreviewed -
4
Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.
Chen L, Ballout F, Chen Z, Thangaretnam K, Que J, Chen XS, McDonald OG, Zaika A, Livingstone A, Giordano S, S… · 2026-06-09
open access unreviewed -
5
From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies.
Fu Y, Tan X, Qin L, Wang C. · 2025-12-05
open access unreviewed -
6
Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice.
Eppler N, Jones E, Ahamed F, Raja N, Akakpo JY, Lebofsky M, He L, Vats I, Ghosh P, Yu Y, Thomas K, McCoin C, … · 2026-04-28
open access unreviewed -
7
Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
Kaddah MMY, Fan TW, Islam JMM, Lin P, Cassel TA, Cunningham R, Brown T, Higashi RM, Lane AN. · 2026-05-13
unreviewed -
8
Shoulder and genetics: what orthopedic surgeons need to know.
Kolac UC, Paksoy A, Erkan DD, Akgun D. · 2026-03-23
open access unreviewed -
9
SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma.
Uprety A, Judd C, Villella ED, Keller R, Wagner R, Robertson KD, Rodriguez-Blanco J, Barnoud T, Mason FM, Ho … · 2026-08-01
unreviewed -
10
Choroid plexus inflammation in bipolar disorder.
Figueroa Velez D, Rahimian R, Hehnly C, Benson JC, Sacharczyk I, Turecki G, Mechawar N, Lehtinen MK. · 2026-04-12
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.