What it does, reaction by reaction
Purine Salvage Pathway Nucleotide Metabolism · Cytosol
Hypoxanthine → IMP
Converts Hypoxanthine into IMP
› Notes
HGPRT catalyzes hypoxanthine + PRPP → IMP + PPi. Mg2+ supports phosphoribosyl transfer, and PPi hydrolysis drives the reaction forward. This is effectively irreversible in vivo and salvages hypoxanthine directly to the central purine intermediate.
Guanine → GMP
› Notes
HGPRT catalyzes guanine + PRPP → GMP + PPi. This is also effectively irreversible in vivo; the same enzyme therefore salvages both hypoxanthine and guanine.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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