Glycogen debranching enzyme (AGL) - amylo-alpha(1,6)-glucosidase activity
Cofactors used
Clinical / pharmacological. Cori-Forbes disease (GSD III)
What it does, reaction by reaction
Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism · Cytosol + ER (liver)
Remaining alpha(1→6)-linked branch glucose + H2O → free glucose
Converts Remaining alpha(1→6)-linked branch glucose H2O into Free glucose
› Notes
The amylo-alpha(1,6)-glucosidase activity of the same glycogen debranching enzyme hydrolyzes the single branch-point residue using water. Approximately one glucose per branch is released free; the reaction is effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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