Glutathione reductase (GSR)
Cofactors used
Clinical / pharmacological. FAD/riboflavin-dependent; links GSH recycling to the pentose phosphate pathway
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
GSSG + NADPH + H+ -> 2 GSH + NADP+
Converts GSSG (oxidised glutathione) NADPH H+ into Glutathione (GSH) NADP+
› Notes
Links antioxidant defence to the pentose phosphate pathway; this is why G6PD deficiency causes oxidative haemolysis. Riboflavin (FAD) dependent.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Engineering functional vasculatures to reconstruct sympathetic-parasympathetic circuits for bladder function after spinal cord injury.
Weng H, Xiao L, Li T, Chang H, Xie P, Zhu L, Zhang B, Lv S, Hu Z, Dai Y, Hoi PM, Liu W, Liu J, Rong L, Ren Y,… · 2026-07-31
open access unreviewed -
2
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18
open access unreviewed -
3
Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation.
Kim SH, Hong SM, Lee EY, Kim SA, Han NS, Kim SY, Lee CH. · 2026-09-12
open access unreviewed -
4
Ferroptosis: significance to zoonotic diseases and therapeutic prospects.
Tian L, Cheng X, Ni J, Yang R, Ouyang W, Qi T, Liu Q, Wang D, Chen H, Wang X. · 2026-08-25
open access unreviewed -
5
Placental PRDX2-VEGFA/ENG network rewiring links oxidative stress to angiogenic failure in preeclampsia: A multi-cohort transcriptomic study.
Kong X, Liu P, Qiao J, Tan Z, Lei L. · 2026-08-10
unreviewed -
6
Interpol review of gunshot residue, 2022 to 2024.
Charles S, Geusens N, Tarenne C, Vanneste F, Nys B. · 2026-08-06
open access unreviewed -
7
Metabolic disruption associated with e-cigarette vaping and secondhand exposure: Urinary metabolomics evidence from a Thai population.
Tajai P, Sawatdikun S, Srisopa T, Konguthaithip G, Parinyarux P, Ditsawanon P, Charoensook P. · 2026-07-11
open access unreviewed -
8
Interpol review of forensic paint, tape, and glass evidence 2022-2025.
Almirall J, Trejos T. · 2026-06-22
open access unreviewed -
9
Interpol review of forensic firearm examination, 2022-2025.
Mattijssen EJAT, Kerkhoff W. · 2026-06-19
open access unreviewed -
10
Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts.
Zhang X, Wang J, Zhou Y, Shen C, Yuan M, Li Q, Li W. · 2026-05-21
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.