What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
PRPP → 5-phosphoribosylamine (5-PRA)
Converts PRPP into 5-Phosphoribosylamine
› Notes
Glutamine-PRPP amidotransferase catalyzes PRPP + glutamine + H2O → 5-PRA + glutamate + PPi. The enzyme uses an internal glutaminase domain to generate ammonia, which is channeled to the phosphoribosyl-transferase domain; PPi hydrolysis drives the reaction forward. This is the committed, rate-limiting, and effectively irreversible step of de novo purine synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)
PRPP
IMP, AMP, and GMP (feedback inhibition; combined nucleotide pools are most effective)
No established direct endocrine regulation; expression/flux increase with growth signals and proliferation.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone.
Xiong T, Shen L, Fan Y, Liu Z, Jin S, Wu H, Yang Z, Niu Y. · 2026-06-02
open access unreviewed -
2
Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment.
Singh NN, Ottesen EW, Singh RN. · 2026-05-25
open access unreviewed -
3
Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance.
Hitti E, Bakheet T, Mahmoud L, Al-Mutairi N, Alhaj L, Al-Zoghaibi F, Khabar KSA. · 2026-02-16
open access unreviewed -
4
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03
open access unreviewed -
5
Cucurbitacin B targets PPAT to suppress de novo purine biosynthesis in esophageal squamous cell carcinoma.
Jia H, Guo J, Luo H, Zhou X, Hou D, Khan A, Xue Y, Dai Z, Qiao Y, Song M, Dong Z. · 2026-06-03
unreviewed -
6
Metabolite glues as a means of purine sensing and chemotherapeutic response.
Witus SR, Kober MM, Roh H, Yang Z, Choueiry F, Ghate AS, Titov DV, Rapé M. · 2026-07-15
unreviewed -
7
Tributyltin-dysregulated periprostatic adipose tissue enhances prostate cell survival and migration, implicating the C-C motif chemokine receptor 3.
Feijó M, Casanova CR, Fonseca LRS, Figueira MI, Brás LA, Catarro G, Gallardo E, Kiss-Toth E, Correia S, Socor… · 2025-06-09
unreviewed -
8
The intersection of race and adiposity in prostate cancer: a narrative review.
Smith M, Lawen T, Garcia RS, Pyo J, Hahn A, Frigo D, Ma H, Wei P, Robert M, Chery L, Chapin BF, Daniel CR, Pe… · 2025-10-20
unreviewed -
9
Assessment of Presence and Metastatic Involvement of Lymph Nodes in Anterior Periprostatic Fat (APPF) in Prostate Cancer Patients Treated with Robotic and Laparoscopic Radical Prostatectomy
Wani M, Abbaraju J, Bhattacharjee B, Omar A, Al-Chalabi H, Madaan S. · 2026-06-01
open access unreviewed -
10
Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.
Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanj… · 2026-06-10
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.