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rate-limiting unreviewed

Glutamine-PRPP amidotransferase

1 reactions · 1 pathways

Cofactors used

H2O PPi PRPP

Clinical / pharmacological. Committed step of purine synthesis; feedback-inhibited by AMP/GMP; azaserine site

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 2 Irreversible rate-limiting

PRPP → 5-phosphoribosylamine (5-PRA)

Converts PRPP into 5-Phosphoribosylamine

› Notes

Glutamine-PRPP amidotransferase catalyzes PRPP + glutamine + H2O → 5-PRA + glutamate + PPi. The enzyme uses an internal glutaminase domain to generate ammonia, which is channeled to the phosphoribosyl-transferase domain; PPi hydrolysis drives the reaction forward. This is the committed, rate-limiting, and effectively irreversible step of de novo purine synthesis.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Accelerated by

PRPP

Inhibited by

IMP, AMP, and GMP (feedback inhibition; combined nucleotide pools are most effective)

Hormonal control

No established direct endocrine regulation; expression/flux increase with growth signals and proliferation.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone.

    Xiong T, Shen L, Fan Y, Liu Z, Jin S, Wu H, Yang Z, Niu Y. · 2026-06-02

    cited 1× open access unreviewed
  2. 2
    Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment.

    Singh NN, Ottesen EW, Singh RN. · 2026-05-25

    cited 1× open access unreviewed
  3. 3
    Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance.

    Hitti E, Bakheet T, Mahmoud L, Al-Mutairi N, Alhaj L, Al-Zoghaibi F, Khabar KSA. · 2026-02-16

    open access unreviewed
  4. 4
    Molecular glue everywhere: Metabolites join the party.

    Wang B, Zheng N. · 2026-10-01

    unreviewed
  5. 5
    Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.

    Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16

    open access unreviewed
  6. 6
    Integrated Transcriptomic and Metabolomic Analyses Reveal Acyl-CoA Dehydrogenase-Mediated Primordium Formation and Metabolite Synthesis in <i>Cordyceps militaris</i>.

    Zhou X, Xue L, Luo Y, Tong X, Guo J. · 2026-09-17

    open access unreviewed
  7. 7
    mpMRI-based clinic-radiomics-deep learning model integrating lesion and PPAT for predicting csPCa in PI-RADS category 3 lesions: a multicenter study.

    Yin L, Shao M, Li B, Rong J, Liu L, Zhang S, Yin X, Xue S, Hou W, Ji Y, Wang X. · 2026-09-15

    unreviewed
  8. 8
    Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency-mediated disease.

    Zafar MA, Hill Machado CN, Behera J, Zhong Y, Li X, Joshi S, El Fazaa Y, Camacho V, Georgiev P, Kurmi K, Haig… · 2026-09-08

    open access unreviewed
  9. 9
    Parallelized 61-Sample Inhibition Screening Accelerated by <sup>19</sup>F-MRI Compressed Sensing.

    Faderl D, Gossert AD, Korvink JG, MacKinnon N. · 2026-09-06

    open access unreviewed
  10. 10
    Characterization of the metabolome and proteome of stem cell-derived human primordial germ cell-like cells: a multi-omics approach.

    Vaz Santos M, Schomakers BV, Ayala ML, Jamali T, van Weeghel M, van Pelt AMM, Mulder CL, Hamer G. · 2026-09-18

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.