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unreviewed

5'-Nucleotidase (NT5C/NT5E)

5 reactions · 2 pathways

Cofactors used

H2O Pi

What it does, reaction by reaction

5 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 1 Irreversible/directional

AMP → adenosine

Converts AMP into Adenosine

› Notes

Cytosolic 5′-nucleotidase catalyzes AMP + H2O → adenosine + Pi. This hydrolytic dephosphorylation is one route for AMP entry into degradation.

step 4 Irreversible/directional

IMP → inosine

Converts IMP into Inosine

› Notes

5′-Nucleotidase catalyzes IMP + H2O → inosine + Pi. Thus AMP that is first deaminated to IMP joins the inosine pathway.

step 8 Irreversible/directional

GMP → guanosine

Converts GMP into Guanosine

› Notes

5′-Nucleotidase catalyzes GMP + H2O → guanosine + Pi.

Pyrimidine Degradation Nucleotide Metabolism · Cytosol

step 1 Irreversible/directional

UMP → uridine

Converts UMP into Uridine

› Notes

5′-Nucleotidase catalyzes UMP + H2O → uridine + Pi. CMP, TMP, and their deoxy counterparts are likewise dephosphorylated by nucleotide phosphatases/nucleotidases before nucleoside or base breakdown.

step 4 Irreversible/directional

TMP → thymidine

Converts dTMP into Thymidine

› Notes

5′-Nucleotidase catalyzes TMP + H2O → thymidine + Pi.

Showing all 5 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Digital twins for in vivo metabolic flux estimations in patients with brain cancer.

    Meghdadi B, Al-Holou WN, Scott AJ, Mittal A, Liang N, Sravya P, Achreja A, O'Brien A, Do K, Wu Z, Feng J, Qi … · 2025-12-01

    cited 1× unreviewed
  2. 2
    Construction of S100 family members prognosis prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study.

    Xu ZJ, Li JA, Cao ZY, Xu HX, Ying Y, Xu ZH, Liu RJ, Guo Y, Zhang ZX, Wang WQ, Liu L. · 2024-06-01

    cited 7× open access unreviewed
  3. 3
    Identification and Validation of Nicotinamide Metabolism-Related Gene Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma.

    Yang S, Li A, Lv L, Duan J, Zheng Z, Zhuo W, Min J, Wei J. · 2024-05-28

    cited 3× open access unreviewed
  4. 4
    Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients.

    Anyanwu SI, Doherty A, Powell MD, Obialo C, Huang MB, Quarshie A, Mitchell C, Bashir K, Newman GW. · 2018-03-12

    cited 23× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.