unreviewed

5'-Nucleotidase (NT5C/NT5E)

5 reactions · 2 pathways

Cofactors used

H2O Pi

What it does, reaction by reaction

5 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 1 Irreversible/directional

AMP → adenosine

Converts AMP into Adenosine

› Notes

Cytosolic 5′-nucleotidase catalyzes AMP + H2O → adenosine + Pi. This hydrolytic dephosphorylation is one route for AMP entry into degradation.

step 4 Irreversible/directional

IMP → inosine

Converts IMP into Inosine

› Notes

5′-Nucleotidase catalyzes IMP + H2O → inosine + Pi. Thus AMP that is first deaminated to IMP joins the inosine pathway.

step 8 Irreversible/directional

GMP → guanosine

Converts GMP into Guanosine

› Notes

5′-Nucleotidase catalyzes GMP + H2O → guanosine + Pi.

Pyrimidine Degradation Nucleotide Metabolism · Cytosol

step 1 Irreversible/directional

UMP → uridine

Converts UMP into Uridine

› Notes

5′-Nucleotidase catalyzes UMP + H2O → uridine + Pi. CMP, TMP, and their deoxy counterparts are likewise dephosphorylated by nucleotide phosphatases/nucleotidases before nucleoside or base breakdown.

step 4 Irreversible/directional

TMP → thymidine

Converts dTMP into Thymidine

› Notes

5′-Nucleotidase catalyzes TMP + H2O → thymidine + Pi.

Showing all 5 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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