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rate-limiting unreviewed

Fructose-1,6-bisphosphatase (FBPase-1)

1 reactions · 1 pathways

Cofactors used

H2O Pi

Clinical / pharmacological. FBPase deficiency: fasting hypoglycaemia, lactic acidosis, ketosis

What it does, reaction by reaction

1 reactions

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 11 Irreversible rate-limiting

Fructose-1,6-bisphosphate + H2O → fructose-6-phosphate + Pi

Converts Fructose-1,6-bisphosphate H2O into Fructose-6-phosphate Pi

› Notes

Fructose-1,6-bisphosphatase (FBPase-1) hydrolyzes the C1 phosphate. This is the key rate-limiting, bypass, and irreversible gluconeogenic reaction opposing PFK-1; it is not the same enzyme as the bifunctional PFK-2/FBPase-2 regulatory protein.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Gluconeogenesis

Listed there as: Fructose-1,6-bisphosphatase

Accelerated by

Citrate

Inhibited by

AMP, fructose-2,6-bisphosphate

Hormonal control

Glucagon lowers fructose-2,6-bisphosphate and favors FBPase-1; insulin raises fructose-2,6-bisphosphate and inhibits it

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma.

    Onieva JL, Pérez-Ruiz E, Vilkki V, Berciano-Guerrero M, Figueroa-Ortiz L, Zalabardo M, Martínez-Gálvez B, Bar… · 2026-03-30

    cited 1× open access unreviewed
  3. 3
    Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy.

    Zheng R, Wang Z, Zhang B, Li Y, Gao S, Guo Y, Meng D, Mu X, Shao L. · 2026-02-09

    cited 2× open access unreviewed
  4. 4
    Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis.

    Chen J, Li Y, Zhou P, Zou S, Zhao J, Wu M, Wang L. · 2026-03-08

    open access unreviewed
  5. 5
    Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.

    Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28

    cited 1× open access unreviewed
  6. 6
    Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism.

    Wu Q, Qiu X, Chen H. · 2026-01-13

    cited 2× open access unreviewed
  7. 7
    Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.

    Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04

    open access unreviewed
  8. 8
    TERT drives liver tumorigenesis beyond telomere elongation.

    Braud L, Vernerey J, Guille A, Cordier P, Ginet C, Egger T, Bernabe M, Churikov D, Da Costa Q, Meghraoui A, D… · 2026-07-02

    unreviewed
  9. 9
    Utilization, metabolic regulation and applications of hydrophobic substrates in <i>Yarrowia lipolytica</i>.

    Zhu F, Zhang L, Wen J. · 2026-02-18

    open access unreviewed
  10. 10
    Fructose-1,6-bisphosphatase as a therapeutic target for type 2 diabetes: from molecular mechanisms to clinical translation.

    Joshi P, Mazumder A, Pentela B, Debnath A. · 2026-08-06

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.