rate-limiting unreviewed

Fructose-1,6-bisphosphatase (FBPase-1)

1 reactions · 1 pathways

Cofactors used

H2O Pi

Clinical / pharmacological. FBPase deficiency: fasting hypoglycaemia, lactic acidosis, ketosis

What it does, reaction by reaction

1 reactions

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 11 Irreversible rate-limiting

Fructose-1,6-bisphosphate + H2O → fructose-6-phosphate + Pi

Converts Fructose-1,6-bisphosphate H2O into Fructose-6-phosphate Pi

› Notes

Fructose-1,6-bisphosphatase (FBPase-1) hydrolyzes the C1 phosphate. This is the key rate-limiting, bypass, and irreversible gluconeogenic reaction opposing PFK-1; it is not the same enzyme as the bifunctional PFK-2/FBPase-2 regulatory protein.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Gluconeogenesis

Listed there as: Fructose-1,6-bisphosphatase

Accelerated by

Citrate

Inhibited by

AMP, fructose-2,6-bisphosphate

Hormonal control

Glucagon lowers fructose-2,6-bisphosphate and favors FBPase-1; insulin raises fructose-2,6-bisphosphate and inhibits it

Recent literature

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