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unreviewed

FGAM synthetase

1 reactions · 1 pathways

Cofactors used

ATP H2O Pi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 5 Irreversible/directional

FGAR → formylglycinamidine ribonucleotide (FGAM)

Converts Formylglycinamide ribonucleotide (FGAR) into Formylglycinamidine ribonucleotide (FGAM)

› Notes

FGAM synthetase catalyzes FGAR + glutamine + ATP + H2O → FGAM + glutamate + ADP + Pi. The glutamine-derived nitrogen becomes N3 of the purine ring; ATP activates the formyl group before amidination.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Per- and polyfluoroalkyl substances in commercially important marine species of fish and shellfish from Alaska and implications for human exposure.

    Furin CG, Burrows J, Cyr AP, Coburn S, Gerlach RF. · 2026-06-25

    unreviewed
  2. 2
    The transfer of per- and polyfluoroalkyl substances (PFAS) from mother to child: Comparison between maternal and cord blood in an Italian cohort.

    Fornasari A, Sech M, Piva E, Morini L, Vaiano F, Seravalli V, Seidenari A, Lenzi J, Simonazzi G, Fais P, Pasc… · 2026-06-30

    unreviewed
  3. 3
    Thraustochytrid PUFA synthase ER domains form a stable heterodimer.

    Lofeudo N, Moncalian G. · 2026-06-10

    unreviewed
  4. 4
    Interpol review of fingermark composition and visualization 2022-2025.

    Bécue A. · 2026-06-13

    open access unreviewed
  5. 5
    Association between PFAS and renal function indicators in cord blood of newborns: modifying effects of newborn sex and maternal factors.

    Yan W, Xu P, Xu Y, Yang W, Huang Q, Mzava SM, Bigambo FM, Wang D, Wang X. · 2026-06-01

    open access unreviewed
  6. 6
    Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin.

    Yi Y, Zhang W, Wei Y, Ran W, Liu D, Deng W, Duan S, Yao J, Wang L, Zhang Y, Gao J, Gong Q. · 2026-02-02

    cited 1× open access unreviewed
  7. 7
    Sex-specific cellular and molecular mechanisms of PFAS-induced reproductive toxicity.

    Bhagwan AS, Gowtham A, Kumar D, Kaundal RK. · 2026-06-30

    unreviewed
  8. 8
    Effects of HFPO-DA (GenX) exposure on placental glycolysis and metabolic microenvironment in pregnant rats.

    Pang Y, Wang Z, Liu Y, Feng C, Song Y, Cao S, Wang D, Zhang L, Lu P, Yu L. · 2026-06-23

    unreviewed
  9. 9
    Perfluorooctanoic acid induces mitochondrial dysfunction-driven apoptosis and PINK1/Parkin-mediated mitophagy in testicular cells.

    Yilmaz BO, Aydin Y. · 2026-06-23

    unreviewed
  10. 10
    A quantitative framework for optimization, interpretation, and quality control of the PFAS total oxidizable precursor assay.

    Zhuang MN, Lao IH, Chen YC, Chang CW, Xiao BK, Liao PC. · 2026-06-03

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.