What it does, reaction by reaction
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
Coupling stoichiometry and P/O outcome: reducing equivalents + ADP + Pi + O2 → ATP + H2O
Converts Reducing equivalents ADP Pi O2 into ATP H2O
› Notes
Thus, about 10 H+ pumped per NADH supports approximately 2.5 ATP, and about 6 H+ per FADH2 supports approximately 1.5 ATP. This P/O relationship is an average bioenergetic estimate, not a fixed invariant, because proton leak, substrate transport, tissue state, and shuttle choice affect observed yields.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease.
Aron E, Meng H, Belperron AA, Filippidis P, Dardick KR, Kleinstein SH, Bockenstedt LK. · 2026-02-23
cited 1× open access unreviewed -
2
Hypothermic machine perfusion prevents hyperacute graft loss in pig-to-primate kidney xenotransplantation after 5-hours of cold Ischemia.
Hisadome Y, Eisenson DL, Chen W, Schulick AC, Luo A, Santillan MR, Casella K, Gu D, Sekijima M, Sahara H, War… · 2025-04-15
cited 1× open access unreviewed -
3
LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes.
Liu J, Cheng Y, Liu Q, Long Q, Liang S, Sun W, Loomes KM, Gao X, Lin B, Liu X, Wu D, Hui HX. · 2025-01-02
cited 1× open access unreviewed -
4
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.
Gill AJ, Smith MD, Galleguillos D, Garton T, Mace JW, Gadani SP, Kumar S, Pokharel A, Solem K, Potluri S, Hus… · 2025-01-28
cited 1× open access unreviewed -
5
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
Sonsalla G, Malpartida AB, Riedemann T, Gusic M, Rusha E, Bulli G, Najas S, Janjic A, Hersbach BA, Smialowski… · 2024-01-23
cited 13× open access unreviewed -
6
Monocyte transcriptomic profile following EPA and DHA supplementation in men and women with low-grade chronic inflammation.
So J, Wu D, Tai AK, Lichtenstein AH, Matthan NR, Lamon-Fava S. · 2023-12-03
cited 4× unreviewed -
7
Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness.
Fleischman JY, Van den Bergh F, Collins NL, Bowers M, Beard DA, Burant CF. · 2023-08-23
cited 8× open access unreviewed -
8
RAIDS atlas of significant genetic and protein biomarkers in cervical cancer.
Scholl S, Roufai DB, Chérif LL, Kamal M. · 2023-09-01
cited 2× open access unreviewed -
9
Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice.
Yamaguchi T, Higa K, Yagi-Yaguchi Y, Ueda K, Noma H, Shibata S, Nagai T, Tomida D, Yasu-Mimura R, Ibrahim O, … · 2020-05-13
cited 39× open access unreviewed -
10
A Drosophila model for genetic analysis of influenza viral/host interactions.
Adamson AL, Chohan K, Swenson J, LaJeunesse D. · 2011-07-20
cited 16× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.