ER-associated squalene synthase
Cofactors used
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
2 FPP + NADPH + H+ → squalene + 2 PPi + NADP+
Converts Farnesyl pyrophosphate (FPP) NADPH H+ into Squalene PPi NADP+
› Notes
ER-associated squalene synthase makes the C30 hydrocarbon through presqualene pyrophosphate. This is the first committed step toward sterol formation after FPP; NADPH is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
2
Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension.
Hu X, Jin H, Li X, Liang Z, Shi J, Zhang H, Zhao J, Li Y, Liu Y, Cheng Y, Liu Y. · 2026-04-07
unreviewed -
3
8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism.
Liu J, Zhao Y, Gong X, Yuan L, Yang S, Jian W, Yan H, Chen H, Yang Z, Sun Y, Gu T, Lu H, Zhao H, Tu Z. · 2025-09-26
open access unreviewed -
4
Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes.
Zarei-Kheirabadi M, Tyc KM, Dain L, Kheirabadi MA, Hanco J, Mockenhaupt K, Munir S, McQuiston A, Singh SK, Ko… · 2026-08-01
open access unreviewed -
5
Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis.
Schuurmans IK, Smajlagic D, Baltramonaityte V, Malmberg ALK, Neumann A, Creasey N, Felix JF, Tiemeier H, Ping… · 2025-09-22
cited 3× unreviewed -
6
Steroid Biosynthesis Pathway Counteracts Iron Overload-Induced Ferroptosis in Mouse Granulosa Cells.
Gao F, Mao W, He X, Liu Y, Liu Y, Liu S, Liu J, Ma L. · 2026-07-17
unreviewed -
7
Β-Sitosterol-imidazolium ionic liquid conjugates: synthesis, computational evaluation, and anticancer activity against colorectal cancer cells.
Seervi S, Vyas S, Rana N, Manhas A, Patel DD, Banerjee J, Mishra R, Banerjee S. · 2026-07-22
unreviewed -
8
Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors.
Hu Q, Wei L, An Z, Wang Y, Zhang T, Wei D. · 2026-06-11
open access unreviewed -
9
Integrated Lipidomic, Transcriptomic, and Metabolomic Analyses Reveal the Regulatory Mechanism Underlying Venom Synthesis in Parotoid Glands of <i>Bufo gargarizans</i>.
Wang Y, Yu X, Peng J, Wang H. · 2026-06-18
unreviewed -
10
<i>Ganoderma lucidum</i> polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.
Jin X, Liu X, Wang YJ, Lei ZL, Yang YH. · 2026-05-22
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.