ER-associated squalene synthase
Cofactors used
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
2 FPP + NADPH + H+ → squalene + 2 PPi + NADP+
Converts Farnesyl pyrophosphate (FPP) NADPH H+ into Squalene PPi NADP+
› Notes
ER-associated squalene synthase makes the C30 hydrocarbon through presqualene pyrophosphate. This is the first committed step toward sterol formation after FPP; NADPH is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
2
Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension.
Hu X, Jin H, Li X, Liang Z, Shi J, Zhang H, Zhao J, Li Y, Liu Y, Cheng Y, Liu Y. · 2026-04-07
unreviewed -
3
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.
Li FF, Cui C, Zheng ZJ, Xiao MY, Li S, Xie P, Piao XL. · 2026-11-01
unreviewed -
4
Genomic relationship between polyendocrine metabolic ovarian syndrome and bipolar disorder.
Jaholkowski P, Tesfaye M, Fominykh V, Parekh P, Wiström ED, Parker N, Koch E, Bauer AE, Trzaskoma P, Rokicki … · 2026-06-25
unreviewed -
5
Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis.
Huang LY, Chen Y, Song LR, Zhong ZL, Ali K, Li HM, Hu QF, Hu HH. · 2026-08-14
open access unreviewed -
6
Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction.
De Bruyn L, Van Beek F, Vander Perre S, Derde S, Derese I, Pauwels L, Van den Berghe G, Langouche L. · 2026-06-18
open access unreviewed -
7
Hepatic cholinergic T cell signaling mediates an adaptive response to alcohol-induced liver stress
· 2026-09-24
open access unreviewed -
8
The Role of the OSM/OSMRβ Axis in Chronic Liver Disease Progression and Hepatocellular Carcinoma Development: A Focus on MASLD/MASH.
Foglia B, Nurcis J, Signorini M, Novo E, Bocca C, Cannito S, Parola M. · 2026-09-15
open access unreviewed -
9
Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules.
Sun Y, Xiao Q, Jin M, Liu G, Zhang Q, Wei X. · 2026-09-18
open access unreviewed -
10
A refined MASH-HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression.
Kim H, Kim G, Yeon H, Yang DY, Lee SG, An TH, Oh SY, Yoon S, Kim J, Choi J, Park HJ, Lee EW, Han BS, Lee CH, … · 2026-09-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.