What it does, reaction by reaction
Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria
25-OH-D or calcitriol -> 24,25-(OH)2-D / calcitroic acid
Converts 25-OH-D or calcitriol into 24,25-(OH)2-D / calcitroic acid
› Notes
Inactivation arm; induced by calcitriol. Loss-of-function causes idiopathic infantile hypercalcaemia.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Biomaterials at the interface of bone-derived factors and inter-organ communication: Current evidence and future perspectives.
Ji L, Zhu F, Wang X, Wang J, Liu C. · 2026-07-13
open access unreviewed -
2
Ubiquitin-specific protease 11 facilitates the activation and proliferation of renal interstitial fibroblasts through epidermal growth factor receptor signaling pathways.
Ma X, Jiang D, Li X, Li J, Hu Y, Wang P, Mo Q, Zhu J, Zhang S, Zhuang S, Shi Y, Liu N. · 2026-05-06
open access unreviewed -
3
Kidney function decline and kidney stone risk: cohort and Mendelian randomization analyses.
Yuan C, Sha L, Xue B, Jiang X, Jian Z. · 2026-04-19
open access unreviewed -
4
Burosumab as bridging therapy in autosomal dominant hypophosphatemic rickets with femoral fracture nonunion and iron deficiency.
Rakusa M, Kocjan T. · 2026-09-15
open access unreviewed -
5
ΔA146Ply exerts anti-triple-negative breast cancer effects by inducing ferroptosis via regulation of the CYP24A1-mediated calcitriol-vitamin D receptor pathway.
Yu Y, Zhang Z, Wang D, Bai X, He D, Ji X, Yin Z, Xu K, Liu J, Zou J. · 2026-08-30
unreviewed -
6
Physiological and transcriptomic changes in zebrafish after long-term exposure from embryo to adult to environmentally relevant concentrations of norgestrel.
Lin H, Wang Q, Liang YQ, Mai S, Zheng Q, Zhou S, Song J, Dong Z, Lin Z. · 2026-08-18
unreviewed -
7
Integrative analysis of transcriptomics and metabolomics reveals mitochondria function genes and associated metabolite pathways in endometritis.
Xu A, Chen Y, Zheng Y, Wen Y, Sun Y, Dong F, Yang H, Fan Y, Yu X. · 2026-07-15
unreviewed -
8
Gene-level variability, pathway-level convergence: A systems view of vitamin D signaling.
Irazoqui AP, Buitrago CG. · 2026-07-08
unreviewed -
9
The 24,25(OH)<sub>2</sub>D<sub>3</sub>-TLCD3B signaling complex and reproductive function in mice and men.
Kooij I, Mitrofanov K, Rehfeld A, Andreassen CH, Kyhn Madsen S, Janssen AM, St-Arnaud R, Jørgensen A, Blomber… · 2026-06-28
unreviewed -
10
Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review
Virtanen J. · 2026-10-08
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.