What it does, reaction by reaction
Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria
25-OH-D or calcitriol -> 24,25-(OH)2-D / calcitroic acid
Converts 25-OH-D or calcitriol into 24,25-(OH)2-D / calcitroic acid
› Notes
Inactivation arm; induced by calcitriol. Loss-of-function causes idiopathic infantile hypercalcaemia.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Ubiquitin-specific protease 11 facilitates the activation and proliferation of renal interstitial fibroblasts through epidermal growth factor receptor signaling pathways.
Ma X, Jiang D, Li X, Li J, Hu Y, Wang P, Mo Q, Zhu J, Zhang S, Zhuang S, Shi Y, Liu N. · 2026-05-06
open access unreviewed -
2
Kidney function decline and kidney stone risk: cohort and Mendelian randomization analyses.
Yuan C, Sha L, Xue B, Jiang X, Jian Z. · 2026-04-19
open access unreviewed -
3
Vitamin D and antimicrobial peptides in skin health and disease: Mechanisms and therapeutic potential.
Gao H, Zhu J, Chen Z, Wang G. · 2026-06-11
open access unreviewed -
4
Effects of vitamin D<sub>3</sub> on embryonic development, transcripts of genes encoding reproductive hormones, and its active metabolism in common carp (Cyprinus carpio L.).
Suder A, Szczygieł J, Kowalik-Chanek K, Drąg-Kozak E, Łuszczek-Trojnar E, Grzesiak M, Socha M. · 2026-08-13
unreviewed -
5
Engineered Extracellular Vesicles Delivering miR-30d-5p Alleviate Osteonecrosis of the Femoral Head.
Xiang XN, Zhang JY, Wang XX, Wang HN, He CQ, Yang L. · 2026-08-11
unreviewed - 6
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7
Mitochondrial Metabolic Biomarkers in Periodontitis: Discovery and Clinical Validation.
Wu J, Wu J, Hong Y, Rao L, Chen M. · 2026-06-13
open access unreviewed -
8
French national diagnosis and care protocol (PNDS) for infantile idiopathic hypercalcemia (IIH).
Amouroux C, Porquet-Bordes V, Adler E, Goff YL, Bacchetta J, Bertocchio JP, Cambonie G, Courbebaisse M, Dicky… · 2026-07-17
unreviewed -
9
Integrative analysis of transcriptomics and metabolomics reveals mitochondria function genes and associated metabolite pathways in endometritis.
Xu A, Chen Y, Zheng Y, Wen Y, Sun Y, Dong F, Yang H, Fan Y, Yu X. · 2026-07-15
unreviewed -
10
Zebrafish frk Gene Knockout Shows Social Impairments Relevant to Autism and Delays Brain Development by Increasing Cell Proliferation.
Lin X, Wu J, Ying Y, Yan B, Wang J, Zou J, Jiang K. · 2026-07-08
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.