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PW-053 Xenobiotic & Drug Metabolism Transport unreviewed

Phase III - Efflux & Excretion

Conjugated metabolite Biliary/urinary/intestinal excretion
Compartment
Plasma membrane (ABC transporters)
Main tissue
Liver, intestine, kidney, blood-brain barrier
Rate-limiting
Not flagged in the source
Steps
1

Reaction steps

In source order, 1 total

showing 1–1
  1. 1

    Conjugated metabolite (intracellular) + ATP -> extracellular metabolite + ADP + Pi

    P-glycoprotein (MDR1/ABCB1); MRP (ABCC) transporters ST-0375 Irreversible/directional ATP
    In Conjugated metabolite (intracellular) ATP
    Out Extracellular metabolite ADP Pi
    › Notes

    ATP-binding-cassette efflux at the canalicular, intestinal and blood-brain barrier membranes; a major source of drug interactions and of tumour multidrug resistance.

Showing all 1 steps.

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