Phospholipid Degradation (Phospholipases)
- Compartment
- Membranes, lysosome, plasma
- Main tissue
- All cells; pancreas, snake/bee venoms
- Rate-limiting
- Phospholipase A2 (cPLA2/sPLA2)
- Steps
- 4
Reaction steps
In source order, 4 total
-
1
Phospholipid -> free fatty acid (sn-1) + 2-acyl-lysophospholipid
› Notes
Cleaves the sn-1 ester bond.
-
2
Phospholipid -> arachidonate (sn-2) + lysophospholipid
› Notes
Cleaves the sn-2 bond and is the rate-limiting release of arachidonic acid for eicosanoid synthesis; inhibited indirectly by glucocorticoid-induced lipocortin/annexin.
-
3
PIP2 -> diacylglycerol + inositol-1,4,5-trisphosphate
› Notes
Cleaves the glycerophosphate bond; generates the two second messengers of the Gq pathway.
-
4
Phosphatidylcholine + H2O -> phosphatidic acid + choline
› Notes
Cleaves distal to the phosphate, releasing the head-group alcohol.
Showing all 4 steps.
Recent literature
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Europe PMC · fetched just now · sorted by publication date
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1
Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.
Guo X, A C, Ding Y, Zhang Y, Zhang H, Wang J, Zhang Y, Wang T. · 2026-09-27
open access unreviewed -
2
Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome.
Andreasen TH, Olsen MH, Vassilieva A, Fenger AW, Lund A, Jensen HR, Forsse A, Møller K. · 2026-10-01
open access unreviewed -
3
Untargeted Lipidomic Profiling Reveals Distinctive Lipid Features in Three Cultivated <i>Fritillaria</i> Species.
Xie G, Liu D, Luo S, Fan W. · 2026-09-11
open access unreviewed -
4
<i>Candida</i><i>tropicalis</i>: An Emerging Opportunistic Pathogen at the Interface of Virulence, Antifungal Resistance, and Host Immune Interactions.
Gómez-Gaviria M, Baruch-Martínez DA, Mora-Montes HM. · 2026-09-12
open access unreviewed -
5
Elucidating the Changes in Metabolites and Physicochemical Quality of Greater Amberjack (<i>Seriola dumerili</i>) During Wet Aging.
Wang D, Wei Y, Li C, Yu G, Cen J, Wu Y, Ma Z, Zhao X, Huang S, Zhao Y. · 2026-09-18
open access unreviewed -
6
Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution.
Permann S, Brunner E, Alsabil K, Werner M, Waltl L, Viault G, D'Avino D, Perkowski B, Siller A, Fritsch L, Pe… · 2026-07-01
open access unreviewed -
7
Uncovering the Metabolic Characterization of Pseudomonas psychrophila and Serratia grimesii Underlying Their Spoilage Potential in Refrigerated Salmon: Based on LC-MS Metabolomics Analysis.
Yi X, Wang Y, Xie J, Mei J. · 2026-09-01
unreviewed -
8
Poultry handling-related stress alters membrane composition, extracellular vesicle production, survival, and virulence in <i>Campylobacter jejuni</i> Bf.
Malet-Villemagne J, D'Mello R, Li Y, Minic Z, Gloux K, Dubois-Brissonnet F, Prost B, Solgadi A, Péchoux C, Co… · 2026-08-14
open access unreviewed -
9
Chilling tolerance in kiwifruit alleviated by brassinosteroid: roles in ROS scavenging, membrane lipid stabilization, and energy metabolism.
Zhang Y, Shen L, Huang Z, Yang C, Yang C, Xie K, Hu H, Chen C, Yang Y, Chen M, Kai W, Zeng J, Chen J, Gan Z. · 2026-04-01
unreviewed -
10
Comprehensive metabolomics and flavoromics analysis reveal the changes in muscle flavor quality of turbot (Scophthalmus maximus) during low-temperature waterless live transport.
Wang S, Sun Y, Sun G, Liu Q, Xue Y, Cao R. · 2026-06-03
unreviewed
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