Phospholipase A2 (cPLA2/sPLA2)
Cofactors used
Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)
What it does, reaction by reaction
Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma
Phospholipid -> arachidonate (sn-2) + lysophospholipid
Converts Phospholipid into Arachidonate (sn-2) Lysophospholipid
› Notes
Cleaves the sn-2 bond and is the rate-limiting release of arachidonic acid for eicosanoid synthesis; inhibited indirectly by glucocorticoid-induced lipocortin/annexin.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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