Phospholipid Degradation (Phospholipases)
- Compartment
- Membranes, lysosome, plasma
- Main tissue
- All cells; pancreas, snake/bee venoms
- Rate-limiting
- Phospholipase A2 (cPLA2/sPLA2)
- Steps
- 4
Reaction steps
In source order, 4 total
-
1
Phospholipid -> free fatty acid (sn-1) + 2-acyl-lysophospholipid
› Notes
Cleaves the sn-1 ester bond.
-
2
Phospholipid -> arachidonate (sn-2) + lysophospholipid
› Notes
Cleaves the sn-2 bond and is the rate-limiting release of arachidonic acid for eicosanoid synthesis; inhibited indirectly by glucocorticoid-induced lipocortin/annexin.
-
3
PIP2 -> diacylglycerol + inositol-1,4,5-trisphosphate
› Notes
Cleaves the glycerophosphate bond; generates the two second messengers of the Gq pathway.
-
4
Phosphatidylcholine + H2O -> phosphatidic acid + choline
› Notes
Cleaves distal to the phosphate, releasing the head-group alcohol.
Showing all 4 steps.
Recent literature
Live Europe PMC search
Europe PMC · from cache · sorted by publication date
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1
Chilling tolerance in kiwifruit alleviated by brassinosteroid: roles in ROS scavenging, membrane lipid stabilization, and energy metabolism.
Zhang Y, Shen L, Huang Z, Yang C, Yang C, Xie K, Hu H, Chen C, Yang Y, Chen M, Kai W, Zeng J, Chen J, Gan Z. · 2026-04-01
unreviewed -
2
Comprehensive metabolomics and flavoromics analysis reveal the changes in muscle flavor quality of turbot (Scophthalmus maximus) during low-temperature waterless live transport.
Wang S, Sun Y, Sun G, Liu Q, Xue Y, Cao R. · 2026-06-03
unreviewed -
3
Protective effects of three natural extracts on ovalbumin-induced intestinal and skin damage in felines via the gut-skin axis: An <i>in vitro</i> study.
Wang H, Liu T, Bai H, Jin H, Wang Z. · 2026-06-08
open access unreviewed -
4
Bifunctional transcription factors: recent advances in growth and development, stress resistance, and quality formation of fruits and vegetables.
Shu P, Zheng Q, You Z, Zhu Y, Cheng X, Qing Y, Yao X, Li J, Shen L. · 2026-03-13
open access unreviewed -
5
Melatonin treatment improves chilling tolerance and maintains quality of postharvest Actinidia arguta fruit by regulating membrane lipid metabolism.
Wu R, Liu X, Wang F, Li S, Wei B, Zhou Q, Sun Y, Cheng S. · 2026-05-14
unreviewed -
6
Cerebral glycerol during haemorrhagic shock in normal and raised intracranial pressure resuscitated with total REBOA: an experimental porcine study.
Bader S, Magnuson A, Brorsson C, Wallin G, Löfgren N, Löfgren F, Blind PJ, Öman M, Olivecrona M. · 2026-06-15
open access unreviewed -
7
Programmed oral delivery of peptide therapeutics for multiorgan targeting in metabolic disorders of hyperglycemia and hyperuricemia.
Liu J, Xing X, Wen C, Chen H, Li W, Huang Y, Wang Y, Xing XH, Zhang CY. · 2026-06-10
open access unreviewed -
8
LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation.
Xu Y, Rajan S, Phoon CKL, Ren M, Hussain MM, Schlame M. · 2026-05-22
open access unreviewed -
9
The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation.
Bose D, Srinivasan K, Patil SS, Nayak AG, Hariharapura RC. · 2026-02-20
open access unreviewed -
10
Phospholipase A2 Isoforms in Lung Immunity and Respiratory Infections: Potential Targets for Next-Generation Therapy.
Joshi S, Walter K, Hamiel D, Saxena D, Zheng J. · 2026-05-25
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.