Hydroxyethyl-TPP
Reactions involving Hydroxyethyl-TPP
Every recorded step where this molecule takes part
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Hydroxyethyl-TPP + oxidized lipoamide (E2) → acetyl-lipoamide + TPP
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Hydroxyethyl-TPP + oxidized lipoamide-E2 → acetyl-dihydrolipoamide-E2 + TPP
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Pyruvate + thiamine pyrophosphate (TPP) → hydroxyethyl-TPP + CO2
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Pyruvate + TPP → hydroxyethyl-TPP + CO2
Showing all 4 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Pyruvate Dehydrogenase Complex (Link Reacti… | → | Pyruvate Oxidation / Link Reaction (Pyruvat… | cross-category |
| Pyruvate Oxidation / Link Reaction (Pyruvat… | → | Pyruvate Dehydrogenase Complex (Link Reacti… | cross-category |
Recent literature
Europe PMC · from cache · sorted by publication date
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1
PIK-III-Mediated Elevation of Thiamine Re-Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1.
Xie D, Wang Y, Cheng W, Yan M, Li K, Wu X, Wu J, Zhang Z, Dai Y. · 2025-07-31
cited 2× open access unreviewed -
2
An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.
Perlatti B, Vellanki S, Zhang Y, Chiang YM, Hu Y, Yuan M, Dunbar K, Fine A, Grau MF, Li S, O'Donnell T, Sheno… · 2026-01-31
open access unreviewed -
3
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential.
Li S, Liu Y, Hu W, Deng A, Ren X, Chen L, Lu Y, Wu Y, Huang H, Cao J, Du J, Xia J, Li Y. · 2025-09-02
cited 3× open access unreviewed -
4
Improving fermentation quality of Sichuan radish paocai through co-inoculation of homo- and heterofermentative lactic acid bacteria.
Fan Y, Guo Q. · 2025-08-25
cited 1× open access unreviewed -
5
The redox landscape of pyruvate:ferredoxin oxidoreductases reveals often conserved Fe-S cluster potentials.
Bonitatibus SC, Pham RV, Weitz AC, Lopéz-Muñoz MM, Li B, Metcalf WW, Nair SK, Elliott SJ. · 2025-06-16
cited 2× open access unreviewed -
6
A Saccharomyces cerevisiae knockout screen for genes critical for growth under sulfur- and nitrogen-limited conditions reveals intracellular sorting via vesicular transport systems.
Simmons S, Graham J, Cobb D, Sudakar S, Teng EG, Lee E, Do ET, Scott L, Price A, Kezh P, Wiles AM. · 2025-07-01
open access unreviewed -
7
Pyruvate dehydrogenase alleviates macrophage autophagy in Hcy-induced ApoE <sup>-/-</sup> mice.
Liu Q, Li F, Hu S, Ding N, Ma F, Hao Y, Li G, Xiong J, Zhang H, Jiang Y. · 2025-02-21
open access unreviewed -
8
<i>CcpA</i>-Knockout <i>Staphylococcus aureus</i> Induces Abnormal Metabolic Phenotype via the Activation of Hepatic STAT5/PDK4 Signaling in Diabetic Mice.
Li Y, Cai J, Liu Y, Li C, Chen X, Wong WL, Jiang W, Qin Y, Zhang G, Hou N, Yuan W. · 2023-10-30
cited 1× open access unreviewed -
9
Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier.
Nguyen Cao TG, Kang JH, Kang SJ, Truong Hoang Q, Kang HC, Rhee WJ, Zhang YS, Ko YT, Shim MS. · 2023-03-31
cited 40× open access unreviewed -
10
A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria.
Bown L, Hirota R, Goettge MN, Cui J, Krist DT, Zhu L, Giurgiu C, van der Donk WA, Ju KS, Metcalf WW. · 2023-04-19
cited 8× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.