Cholesterol
Reactions involving Cholesterol
Every recorded step where this molecule takes part
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Cholesterol + O2 + NADPH -> 7-alpha-hydroxycholesterol
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consumed Cholesterol 7-alpha-hydroxylase (CYP7A1) Lipoprotein Metabolism (Exogenous and End… ST-0132
Hepatic cholesterol → bile acids/free cholesterol → biliary secretion or enterohepatic recycling
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produced Monoacylglycerol acyltransferase + DGAT + ACAT2 (enterocyte) Lipoprotein Metabolism (Exogenous and End… ST-0117
Fatty acids/monoacylglycerol + enterocyte re-esterification → TAG; cholesterol → cholesteryl ester
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produced SR-BI (selective uptake) / CETP (cholesteryl ester transfer protein) Lipoprotein Metabolism (Exogenous and End… ST-0131
HDL cholesteryl ester → liver directly or to apoB particles indirectly
Showing all 4 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Lipoprotein Metabolism (Exogenous and Endog… | → | Bile Acid Synthesis | within category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.
Huang J, Sun L, Yue L, Xu L, Liu H, Ma P, Xiao P. · 2026-07-04
unreviewed -
2
Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.
He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H. · 2026-06-19
unreviewed -
3
Carryover effects of dietary arginine on productive performance and blood biochemistry in Japanese quail (<i>Coturnix japonica</i>).
Gashew M, Reda GK, Knop R, Szabó C, Lendvai ÁZ, Czeglédi L. · 2026-07-19
unreviewed -
4
Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study.
Rao J, Li Y, Qian W, Zhang Y, Dou X, Cao H, Ye Z, Peng H. · 2026-07-17
unreviewed -
5
Microbiota-liver axis and host transcriptomic mechanisms underlying the anti-obesity effects of Bifidobacterium animalis DPU-MWFBA in early-life overfeeding.
Gao Z, Zhao B, Mu G, Nie H, Wu X. · 2026-06-27
unreviewed -
6
Smoking status and determinants among Iranian adults with diabetes: findings from the national STEPS 2021 survey.
Behgam N, Salehi S, Akbarpour S, Tabatabaei-Malazy O, Mozafari S, Asgari S, Rezaei N. · 2026-06-26
unreviewed -
7
Therapeutic frontiers in ALS: iPSC-based drug discovery, cell therapy, and gene therapy-Advances through 2026.
Morimoto S, Kato C, Takahashi S, Okano H. · 2026-06-15
open access unreviewed -
8
Anti-gallstone effects of Jieshiqing Capsule and its active component verbascoside and the underlying mechanisms.
Yongbo X, Li X, Chen H, Jiang K, Xia W, Feng Y, He M. · 2026-06-24
unreviewed -
9
A comprehensive review on Jiao-tai-wan: Traditional application, pharmacokinetics, and therapeutic mechanisms in multiple disorders.
Nan F, Xu W, Wang X, Miao Q, Sun J, Zhao R, Li X, Zhou Y, Xie X, Pang X. · 2026-06-23
unreviewed -
10
Bovine coronavirus enters PBIECs via membrane fusion and clathrin-, caveolin-mediated endocytosis, macropinocytosis.
Chen C, Su N, Zhao L, Li N, Ma Z, Luo B, Liu W, Song B, Zhang L, Guo K. · 2026-06-24
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.