Cytosolic glycerol-3-phosphate dehydrogenase (GPD1)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Dihydroxyacetone phosphate + NADH + H+ ⇌ glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic glycerol-3-phosphate dehydrogenase supplies glycerol-3-phosphate from glycolytic DHAP, the predominant adipocyte source. This reaction couples TAG synthesis to glucose uptake and glycolysis.
Glycerol-3-Phosphate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Dihydroxyacetone phosphate + NADH + H+ -> glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic half of the shuttle.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.
Prasadani M, Jaakson H, Karis P, Muhandiram S, Henno M, Kuusik S, Ling K, Rajapaksha H, Ots M, Andronowska A,… · 2026-05-01
cited 1× open access unreviewed -
2
Lipid remodeling enables adaptation to chronic hyperosmotic stress
Williams T, Klose C, Ernst R, Carvalho P. · 2026-10-08
open access unreviewed -
3
Lactiplantibacillus plantarum CM48 modulates protein metabolism in fermented lamb sausages: A Metaproteomics-based model.
Wang D, Yang X, Cheng F, Jin Y, Tian J. · 2026-09-17
open access unreviewed -
4
Cell Type-Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment.
Lucart-Sanchez AM, Sellés-Climent E, Navarro-Calvo J, Pont-Espinós G, Gomez-Sanchez JA, Estévez R, Valor LM, … · 2026-10-01
open access unreviewed -
5
Spatiotemporal regulation of neutrophil-mediated immune cascades via engineered PEEK surfaces restores osseointegration in diabetes.
Tan J, Yang D, Qin L, Chen Z, Xu Z, Wei C, Chen J, Huang Y, Yang D, Fang Y, Tang M, Wen H, Yi W, Gao A, Zhang… · 2026-05-21
cited 2× open access unreviewed -
6
Endophytic Pseudomonas oryzihabitans CB24 Boosts Photosynthesis Through Monogalactosyldiacylglycerol Driven Lipid Reprogramming.
Deepa N, Chauhan S, Trivedi PK, Singh A. · 2025-08-29
cited 2× unreviewed -
7
Palmitoleic acid n7 improves glucose uptake and metabolism and attenuates oxidative stress in human visceral adipocytes.
Lisboa NADS, Mawandji NBS, Vieira JM, da Silva Kefner AC, Oliveira PM, Nunes KZ, de Souza PHO, Haraguchi FK, … · 2026-09-28
open access unreviewed -
8
Urban Tree Pathogens: The Impact of Neofusicoccum luteum on Araucaria heterophylla (Norfolk Island Pine).
Petrova A, Pratt C, Bar I, T Sambasivam P, Michael RN. · 2026-09-28
open access unreviewed -
9
Parvovirus B19 and Cellular Transcriptome Dynamics in UT7/EpoS1 Cells.
Guglietta N, Bichicchi F, Gasperini I, Manaresi E, Gallinella G. · 2026-09-08
open access unreviewed -
10
<i>BnVTE2</i>-Mediated Vitamin E Modulation Is Associated with Antioxidant Capacity, Fatty Acid Stability, and Seed Longevity in <i>Brassica napus</i>.
Ruan Q, Tan X, Hussain W, Zeng Y, Zhou Y. · 2026-09-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.