Cytosolic glycerol-3-phosphate dehydrogenase (GPD1)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Dihydroxyacetone phosphate + NADH + H+ ⇌ glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic glycerol-3-phosphate dehydrogenase supplies glycerol-3-phosphate from glycolytic DHAP, the predominant adipocyte source. This reaction couples TAG synthesis to glucose uptake and glycolysis.
Glycerol-3-Phosphate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Dihydroxyacetone phosphate + NADH + H+ -> glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic half of the shuttle.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.
Prasadani M, Jaakson H, Karis P, Muhandiram S, Henno M, Kuusik S, Ling K, Rajapaksha H, Ots M, Andronowska A,… · 2026-05-01
open access unreviewed -
2
Spatiotemporal regulation of neutrophil-mediated immune cascades via engineered PEEK surfaces restores osseointegration in diabetes.
Tan J, Yang D, Qin L, Chen Z, Xu Z, Wei C, Chen J, Huang Y, Yang D, Fang Y, Tang M, Wen H, Yi W, Gao A, Zhang… · 2026-05-21
open access unreviewed -
3
Metabolic engineering and adaptive laboratory evolution enhance squalene production in <i>Yarrowia lipolytica</i>.
Zhao QQ, Hu PC, Zhang CJ, Zhu MY, Tian Y, Yang XN, Ji XJ, Li CZ, Sun XM, Lu XY, Liu HH. · 2026-01-30
open access unreviewed -
4
SNORA11B recruits SWI/SNF to suppress esophageal squamous cell carcinoma malignancy by promoting GPD1-mediated G3P accumulation and mitochondrial damage.
Hu L, Lu W, Huang Z, Liu D, Chen X, Ma X, Liu Z, Zhang Y. · 2026-07-07
unreviewed -
5
Glycerol-3-Phosphate Dehydrogenase 1 (GPD1) Deficiency: A Transient Disease or a Great Masquerader?
Das S, Biswas T. · 2026-04-30
unreviewed -
6
Founder Effect of the c.500G>A Variant in South Asian Patients With Inherited GPD1 Deficiency: Report on 16 Patients and Variant Review.
Malik I, Banday AZ, Bhat AS, Jan UM, Reshie AA, Fayaz F, Basharat S, Wani NA. · 2026-03-16
cited 2× unreviewed -
7
Causal association between antidiabetic drug targets and risk of Bell's palsy: A 2-sample Mendelian randomization study.
Lu K, Ye L, Yi X, He Y. · 2026-07-01
unreviewed -
8
GPD1-mediated neuronal lipotoxicity drives aconitine-induced mitochondrial collapse and lethality.
Jiang C, Hu W, Deng S, Huang Y, Wang L, Yang Z, Li Y, Li P, Wu H. · 2026-04-29
unreviewed -
9
APOA1, DEFB103A_DEFB103B and DSG3 Are Novel Circulating Biomarkers of Psoriasis.
Dźwigała M, Sys D, Życka-Krzesińska J, Rybicka B, Popławski P, Walecka-Herniczek I, Piekiełko-Witkowska A, Bo… · 2026-06-26
unreviewed -
10
Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in LPL, APOC2, APOA5, GPIHBP1, LMF1, APOE and Polygenic Risk
Blokhina A, Meshkov A, Ershova A, Zaicenoka M, Mikhailina V, Smetnev S, Bukaeva A, Limonova A, Kiseleva A, So… · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.