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unreviewed

Cytosolic acetoacetyl-CoA thiolase

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid)

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 1 Reversible

2 acetyl-CoA → acetoacetyl-CoA + CoA-SH

Converts Acetyl-CoA into Acetoacetyl-CoA CoA-SH

› Notes

Cytosolic acetoacetyl-CoA thiolase condenses two acetyl-CoA molecules. This reversible reaction supplies the C4 intermediate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Research progress of ferroptosis in gynecological diseases.

    Chen W, Zhou W, Liu S. · 2026-06-19

    open access unreviewed
  2. 2
    MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.

    Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15

    open access unreviewed
  3. 3
    Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.

    Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10

    open access unreviewed
  4. 4
    Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens.

    Li J, Xu Y, Ren P, Xiong X, Qiu M, Yu C, Liu Y, Yang C. · 2026-02-03

    open access unreviewed
  5. 5
    Acetoacetyl-CoA synthetase modulates lipid partitioning and cholesterol-related gene expression in NEFA-challenged neonatal bovine hepatocytes.

    Tian Y, Wang S, Loor JJ, Fan W, Chang Y, Yang T, Zhang B, Xia C, Xu C, Li X, Yang W. · 2026-05-11

    unreviewed
  6. 6
    Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review).

    Wu Y, Yu H, Xia L, Yang L, Zhou Y, Yu Q. · 2026-06-11

    open access unreviewed
  7. 7
    Systems pharmacology approaches to modeling immune training and tolerance.

    Kırboğa KK, Rudrapal M. · 2026-04-21

    unreviewed
  8. 8
    Characteristics of pyripyropene fungal alkaloids and synthetic derivatives targeting ACAT2 as insecticides, anti-atherosclerosis and anticancer agents.

    Bailly C. · 2026-07-24

    unreviewed
  9. 9
    Deciphering the impact of <i>SNAI1</i> gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics.

    Kanlaya R, Nonthawong K, Suntivichaya M, Yoodee S, Thongboonkerd V. · 2025-11-10

    open access unreviewed
  10. 10
    Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics.

    Li W, Xu J, Long Y, Zhang H, Rong X, Su Z. · 2025-11-19

    cited 1× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.