Cytosolic acetoacetyl-CoA thiolase
Cofactors used
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
Converts Acetyl-CoA into Acetoacetyl-CoA CoA-SH
› Notes
Cytosolic acetoacetyl-CoA thiolase condenses two acetyl-CoA molecules. This reversible reaction supplies the C4 intermediate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Circadian reprogramming of inflammation and metabolism in chronic kidney disease.
Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06
open access unreviewed -
2
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
3
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
4
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10
open access unreviewed -
5
Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens.
Li J, Xu Y, Ren P, Xiong X, Qiu M, Yu C, Liu Y, Yang C. · 2026-02-03
cited 2× open access unreviewed -
6
Targeting lipid metabolic vulnerabilities with small-molecule inhibitors in acute myeloid leukemia: Emerging insights and therapeutic opportunities.
Yen JH, Phan TQ, Liou JW, Chen PY. · 2026-07-25
open access unreviewed -
7
Subtype-specific mechanisms of lipid metabolism in gynecological malignancies and novel targeted intervention strategies (Review).
Ran Y. · 2026-08-04
open access unreviewed -
8
PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway.
Ariav Y, Hayek S, Cantore T, Sanghvi N, Adler LN, Darzi N, Pal LR, Crawford DR, Malleron T, Silverbeck J, Yar… · 2026-10-01
open access unreviewed -
9
Identification of Gβ5 Interactome Associated with Neuronal Development in Neuro-2a Cells through miniTurbo Proximity Labeling.
McNabb HJ, Zhang J, Jewell CP, Yang W, Jenkins LM, Simonds WF. · 2026-09-14
open access unreviewed -
10
Fruit- and Vegetable-Derived Exosome-like Nanovesicles: A Review.
Nie Y, Li N, Zhu HT, Zhang YJ. · 2026-09-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.