Cystathionine gamma-lyase (CGL/CSE)
Cofactors used
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Cystathionine + H₂O → L-cysteine + α-ketobutyrate + NH₄⁺
Converts Cystathionine H2O into Cysteine Alpha-ketobutyrate NH4+
› Notes
Cystathionine γ-lyase (CGL/CSE) is PLP-dependent and completes transsulfuration. α-Ketobutyrate is oxidatively decarboxylated to propionyl-CoA and can yield succinyl-CoA through the biotin- and cobalamin-dependent propionate pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03
open access unreviewed -
2
A universal consuming endogenous H<sub>2</sub>S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance.
Lin Y, Yuan K, Liu Y, Du Y, Chang H, Hou L, Liang Y, Huang K, Yang S, Tang T. · 2026-08-18
open access unreviewed -
3
Spontaneous resolution of cerebrospinal fluid obstruction due to intraventricular hemorrhage: A case report.
Shrestha S, Davila-Siliezar P, Duarte-Celada W. · 2026-09-21
open access unreviewed -
4
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18
open access unreviewed -
5
Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report.
Liu YH, Hung PL. · 2026-09-18
open access unreviewed -
6
p-Brain: A Modular Open-Source Framework for Automated Quantitative DCE-MRI of Cerebral Perfusion, Microvasculature, and Blood-Brain Barrier Permeability.
Tireli ED, Cramer SP, Lindberg U, Tireli D, Vestergaard MB, Larsson HBW. · 2026-08-13
open access unreviewed -
7
Emerging bioactive microneedle platforms for disease management: From cutaneous disorders to systemic therapeutics.
Xiang Y, Gong Z, Liu J, Zhu Y, Zhang Z, Li B, Luo J, Su M, Yeung KWK. · 2026-07-22
open access unreviewed -
8
Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.
Hahad O, Kuntic M, Al-Kindi S, Lelieveld J, Cheng Y, Schmitt VH, Hobohm L, Keller K, Kerahrodi JG, Faridi S, … · 2026-06-26
open access unreviewed -
9
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed -
10
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.
Zhang Y, Xin Y, Zhou J, Yang G, Li S. · 2026-06-05
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.