Cystathionine gamma-lyase (CGL/CSE)
Cofactors used
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Cystathionine + H₂O → L-cysteine + α-ketobutyrate + NH₄⁺
Converts Cystathionine H2O into Cysteine Alpha-ketobutyrate NH4+
› Notes
Cystathionine γ-lyase (CGL/CSE) is PLP-dependent and completes transsulfuration. α-Ketobutyrate is oxidatively decarboxylated to propionyl-CoA and can yield succinyl-CoA through the biotin- and cobalamin-dependent propionate pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.
Hahad O, Kuntic M, Al-Kindi S, Lelieveld J, Cheng Y, Schmitt VH, Hobohm L, Keller K, Kerahrodi JG, Faridi S, … · 2026-06-26
unreviewed -
2
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed -
3
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.
Zhang Y, Xin Y, Zhou J, Yang G, Li S. · 2026-06-05
open access unreviewed -
4
Analytical and clinical validation of a competitive ELISA for serum indoxyl sulfate and its clinical association with chronic kidney disease risk stratification.
Hou YC, Chuang YC, Cheng YW, Huang HY, Chen LY, Tseng TL, Lu KC. · 2026-06-02
open access unreviewed -
5
Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay.
Kumar R, Banerjee R. · 2026-06-02
open access unreviewed -
6
Towards best practice recommendations: Perspectives from Australian GPs to inform the use of general practice data for research - A modified Delphi study.
Green H, Beilby J, Degeling C, Adams C, Flack F, Carolan L, Fabrianesi B, Brown A, Nettel Aguirre A, Clarke A… · 2026-01-09
open access unreviewed -
7
Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.
Simão S, Santos DF, Teixeira M, Agostinho RR, Rodrigues J, Vitorino M, Araújo IM. · 2025-12-15
cited 3× open access unreviewed -
8
Genres and typologies of standard paediatric service public funding model provisions for speech-language pathology management: A scoping review.
Nickless T, Davidson B, Gold L, Dowell R. · 2026-05-19
open access unreviewed -
9
Elucidating the synergistic mechanism of Ni-CeO<sub>2</sub> solid solutions in the catalytic transfer hydrogenation of levulinic acid.
Jing F, Wang L, Liu C, Xiang H, Luo S. · 2026-05-18
unreviewed -
10
Predictive modeling of Staphylococcus aureus growth and enterotoxin production in chicken cuts.
Flores GC, Peixoto IA, de Souza BN, Gonçalves CTH, Cacciatore FA, de Oliveira Elias S, Tondo EC. · 2026-06-14
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.