Cystathionine gamma-lyase (CGL/CSE)
Cofactors used
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Cystathionine + H₂O → L-cysteine + α-ketobutyrate + NH₄⁺
Converts Cystathionine H2O into Cysteine Alpha-ketobutyrate NH4+
› Notes
Cystathionine γ-lyase (CGL/CSE) is PLP-dependent and completes transsulfuration. α-Ketobutyrate is oxidatively decarboxylated to propionyl-CoA and can yield succinyl-CoA through the biotin- and cobalamin-dependent propionate pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first