What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Arachidonic acid + 2 O2 -> PGG2 -> PGH2
Converts Arachidonic acid O2 into PGG2
› Notes
Bifunctional cyclooxygenase + peroxidase. Irreversibly acetylated by aspirin; reversibly inhibited by other NSAIDs; COX-2 selectively inhibited by coxibs.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Vitamin E-Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis-Generating Multi-Omics Analysis.
Ma Y, Han Y, Geng Z, Fang S, Ren J, Wang S, He T, Kong L, Fang M. · 2026-08-06
unreviewed -
2
Neuronal Injury and Regeneration-Linked Gene Expression Dynamics in the Hypothalamic–Pituitary–Adrenal Axis Following Experimental Traumatic Brain Injury
Ulutabanca H, Albayrak S, Yilmaz Şükranli Z, Er B, Abat E, Taheri S. · 2026-06-01
open access unreviewed -
3
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women.
Geyton TA, Cole SW. · 2026-05-17
open access unreviewed -
4
Commentary on “Examining the Evidence Around Acetaminophen and Autism Risk”
Myers K, Kearns G. · 2026-06-01
unreviewed -
5
Unveiling medication patterns in traditional Chinese medicine for the prevention of colorectal cancer recurrence: from potential combinations to validation of components and targets.
Bu Q, Yuan S, Wei X, Wang J, Li L, Chen P, Shen W, Sun D, Ye LL, Yang Y, Xu L, Lu S, Duan DD, Cheng H. · 2026-06-04
open access unreviewed -
6
Self-nanoemulsifying drug delivery system (SNEDDS) enhances the antidiabetic potential of <i>Averrhoa bilimbi</i> L. leaf extract: Integrated LC-MS/MS metabolomics, network pharmacology, and alpha-amylase inhibition.
Aryani R, Sarah S, Yuniarni U, Syabihah H, Fakih TM. · 2026-04-23
open access unreviewed -
7
GLIS3, a novel regulator of eicosanoid gene expression and metabolism in normal kidney and polycystic kidney disease.
Srivastava C, Kang HS, Edin ML, Mukherjee T, Lih FB, Grimm SA, Collier JB, Zeldin DC, Jetten AM. · 2026-02-11
unreviewed -
8
Network Analysis of Convergent and Specific Molecular Pathways of Nutraceuticals with Antioxidant and Neuroprotective Potential in Glaucoma.
Teneva P, Stamova S, Varlyakov K, Ermenlieva N, Georgieva E, Kostadinova T. · 2026-04-02
open access unreviewed -
9
Aspirin alters molecular crosstalk between prostaglandin, apoptosis, and invasion pathways in colorectal cancer.
Mostafavi-Fini HS, Moradi A, Gowdini E, Mohammadi R, Abdollahi T, Jamshidian F, Ganji SM. · 2026-04-14
open access unreviewed -
10
Mechanism-based prediction of drug synergy via network controllability analysis of therapeutic pathways in intractable diseases.
Namba S, Goda M, Kuniki Y, Ishizawa K, Iida M, Takeshita JI, Yamanishi Y. · 2026-03-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.