What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Arachidonic acid + 2 O2 -> PGG2 -> PGH2
Converts Arachidonic acid O2 into PGG2
› Notes
Bifunctional cyclooxygenase + peroxidase. Irreversibly acetylated by aspirin; reversibly inhibited by other NSAIDs; COX-2 selectively inhibited by coxibs.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking.
Chen M, Ding N, Qiu X, Li L, Guo Y, Wang R, Mo X, Zou T, Yu S, Li X, Chen J. · 2026-10-01
open access unreviewed -
2
Curvilinear associations of discrimination attributions with inflammatory and antiviral gene expression.
Crump AA, Bather JR, Rodrigues M, Binns AA, Kranz EO, Cole SW, Cuevas AG. · 2026-07-29
unreviewed -
3
Integrating Pharmacodynamic Data to Prioritise Candidate Migraine Genes and Pathways Using a Novel Bioinformatics Workflow.
Stanworth M, Peukert T, Marley J, Puddifoot C, McDowell A, Murray E, Zhang SD. · 2026-09-11
open access unreviewed -
4
Transcription Factor XBP1s Impairs Endometrial Receptivity by Promoting ENO1-Mediated Glycolysis and Lactate Production.
Gao K, Si M, Wang H, Zhang H, Zhu F, Lin P, Chen H, Zheng X, Jin Y. · 2026-09-14
open access unreviewed -
5
An Ex Vivo Model for the Onset of Human Labor.
Paul M, Barreda AP, Gregson A, King M, Hossain MR, Hussein WM, Walker FR, Smith R, Zakar T, Paul JW. · 2026-09-23
open access unreviewed -
6
CP1Hao Decoction Alleviates Chronic Prostatitis by Modulating Arachidonic Acid Metabolism: A Multi-Omics Analysis.
Lei LX, Chang HR, Feng JL, Xia Y, Chen H, Lin XF, Li KC, Sun LJ, Wang L, Wang JS. · 2026-09-04
open access unreviewed -
7
The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options.
Luo C, Xia N, Hui SY, Wong US, Tsang JY, Hu H, Tsang CM, Lo KW, Sun P, Shao M, Alahari SK, Kang W, Tse GM, Gu… · 2026-08-07
open access unreviewed -
8
Microbiota-Dependent Alleviation of Ulcerative Colitis by Liubao Tea: Integrated Insights into SCFA and Arachidonic Acid Metabolism.
Yang X, Xu S, Tong Y, Luo J, Fang X, Du J, Zhou C, Hu G, Yang B, Zhang Q. · 2026-08-31
open access unreviewed -
9
Toward Personalized NSAID Therapy in Osteoarthritis: The Right Patient, the Right Treatment, at the Right Time.
Zarnescu VC, Mititelu-Tartau L, Onu I, Iordan DA, Pavel LL. · 2026-08-08
open access unreviewed -
10
Integrative Single-Cell and Spatial Transcriptomic Analyses Link Arachidonic Acid Metabolic Reprogramming to Proneural-to-Mesenchymal State Transition in Glioblastoma.
Peng S, Wen Z, Cai XT. · 2026-08-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.