Catechol-O-methyltransferase (COMT) + monoamine oxidase (MAO)
Cofactors used
Clinical / pharmacological. MAOI + tyramine: hypertensive crisis
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
Catecholamines -> metanephrines/normetanephrine -> vanillylmandelic acid (VMA)
Converts Catecholamines into Metanephrines/normetanephrine
› Notes
Urinary metanephrines and VMA are the screening metabolites for phaeochromocytoma; dopamine degrades to homovanillic acid.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis.
Cheung N. · 2026-04-17
open access unreviewed -
2
Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease.
Duong MT, Das SR, Khandelwal P, Lyu X, Xie L, McGrew E, Dehghani N, McMillan CT, Lee EB, Shaw LM, Yushkevich … · 2025-05-01
cited 14× unreviewed -
3
Contribution of dopaminergic polymorphisms to levodopa treatment response and drug concentration in Chinese patients with Parkinson's disease.
He X, Shi K, Mo C, Zhang Y, Xiao Q, Yang X. · 2025-04-20
open access unreviewed -
4
Dopaminergic Epistases in Schizophrenia.
Bosun A, Albu-Kalinovic R, Neda-Stepan O, Bosun I, Farcas SS, Enatescu VR, Andreescu NI. · 2024-10-29
cited 3× open access unreviewed -
5
Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development.
Yu Z, Huang P, Wang L, Meng F, Shi Q, Huang X, Qiu L, Wang H, Kong S, Wu J. · 2024-08-07
cited 2× open access unreviewed -
6
The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models.
MacDonald HJ, Kleppe R, Szigetvari PD, Haavik J. · 2024-11-15
cited 41× open access unreviewed -
7
Application of OpenArray Technology to Assess Changes in the Expression of Functionally Significant Genes in the Substantia Nigra of Mice in a Model of Parkinson's Disease.
Troshev D, Kolacheva A, Pavlova E, Blokhin V, Ugrumov M. · 2023-12-12
cited 2× open access unreviewed - 8
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9
<i>Gpr88</i> Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine.
Spark DL, Vermeulen MH, de la Fuente Gonzalez RA, Hatzipantelis CJ, Rueda P, Sepehrizadeh T, De Veer M, Manno… · 2022-11-11
cited 2× open access unreviewed -
10
Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats.
Aranäs C, Edvardsson CE, Shevchouk OT, Zhang Q, Witley S, Blid Sköldheden S, Zentveld L, Vallöf D, Tufvesson-… · 2023-06-07
cited 127× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.