Catechol-O-methyltransferase (COMT) + monoamine oxidase (MAO)
Cofactors used
Clinical / pharmacological. MAOI + tyramine: hypertensive crisis
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
Catecholamines -> metanephrines/normetanephrine -> vanillylmandelic acid (VMA)
Converts Catecholamines into Metanephrines/normetanephrine
› Notes
Urinary metanephrines and VMA are the screening metabolites for phaeochromocytoma; dopamine degrades to homovanillic acid.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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