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unreviewed

COMT / TPMT / methyltransferases

1 reactions · 1 pathways

Cofactors used

SAM

Clinical / pharmacological. TPMT deficiency: azathioprine/6-MP myelosuppression

What it does, reaction by reaction

1 reactions

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 5 Irreversible/directional

Substrate + SAM -> methylated metabolite + SAH

Converts S-adenosylmethionine (SAM) into S-adenosylhomocysteine

› Notes

TPMT deficiency causes severe myelosuppression with azathioprine and 6-mercaptopurine.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model.

    Fan X, Ding X, Zhang QY. · 2019-12-12

    cited 18× open access unreviewed
  2. 2
    Genetic Variants as Predictive Markers for Ototoxicity and Nephrotoxicity in Patients with Locally Advanced Head and Neck Cancer Treated with Cisplatin-Containing Chemoradiotherapy (The PRONE Study).

    Driessen CM, Ham JC, Te Loo M, van Meerten E, van Lamoen M, Hakobjan MH, Takes RP, van der Graaf WT, Kaanders… · 2019-04-17

    cited 16× open access unreviewed
  3. 3
    Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells.

    Wu M, Zhao G, Zhuang X, Zhang T, Zhang C, Zhang W, Zhang Z. · 2018-05-18

    cited 20× open access unreviewed
  4. 4
    TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.

    Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, W… · 2017-06-01

    cited 55× unreviewed
  5. 5
    An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.

    Karasawa T, Steyger PS. · 2015-06-20

    cited 340× unreviewed
  6. 6
    Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics.

    Travis LB, Fossa SD, Sesso HD, Frisina RD, Herrmann DN, Beard CJ, Feldman DR, Pagliaro LC, Miller RC, Vaughn … · 2014-03-12

    cited 88× unreviewed
  7. 7
    Chemotherapy refractory testicular germ cell tumor is associated with a variant in Armadillo Repeat gene deleted in Velco-Cardio-Facial syndrome (ARVCF).

    Fung C, Vaughn DJ, Mitra N, Ciosek SL, Vardhanabhuti S, Nathanson KL, Kanetsky PA. · 2012-12-13

    cited 10× open access unreviewed
  8. 8
    Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.

    Weinshilboum RM. · 2006-06-29

    cited 38× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.