rate-limiting unreviewed

Bilirubin UDP-glucuronosyltransferase (UGT1A1)

1 reactions · 1 pathways

Cofactors used

UDP-glucuronic acid

Clinical / pharmacological. Gilbert syndrome (mild), Crigler-Najjar types I and II

What it does, reaction by reaction

1 reactions

Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut

step 4 Irreversible/directional rate-limiting

Bilirubin + 2 UDP-glucuronic acid → bilirubin mono- and predominantly diglucuronide + 2 UDP

Converts Bilirubin UDP-glucuronate into Bilirubin diglucuronide UDP

› Notes

Endoplasmic-reticulum bilirubin UDP-glucuronosyltransferase (UGT1A1) conjugates the two propionic-acid side chains using UDP-glucuronic acid. This is the rate-limiting enzymatic step of hepatic bilirubin clearance and produces water-soluble conjugated bilirubin; bilirubin diglucuronide is then actively secreted into bile by the ATP-dependent canalicular transporter MRP2 (ABCC2).

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Digeda-8 formula attenuates cholestatic liver injury in rats by restoring bile acid transport and suppressing inflammation: An integrated metabolomics and proteomics approach.
Bayoude A, Yi R, Zhao Y, Runa A, Ming M, Hu S, Jirimu B. · 2026-06-24

unreviewed
2
Gut bacterial O-demethylation modulates systemic exposure to oral etoposide.
Tripathi A, Kyawt TE, Shin J, Won KJ, Armstrong AT, Ilktach G, Sullivan P, Weilbaker HA, Ko Y, Lee S, Lee W, … · 2026-02-13

open access unreviewed
3
Toxicity assessment of three emerging bisphenols (BPA, BPAP and BPC) and their binary mixtures in an advanced in vitro 3D HepG2 cell model.
Štampar M, Ravnjak T, Štern A, Žegura B. · 2026-07-01

unreviewed
4
Structure-based machine learning model for discovering pregnane X receptor (PXR) agonists and biological activity validation.
Huang FF, Luo Y, Chen H, Meng YH, Li W, Liang H, Ai CZ. · 2026-05-25

unreviewed
5
Role of pregnane X receptor in the upregulation of human aldehyde oxidase gene expression.
Chen S, Mettu VS, Lau AJ. · 2026-05-23

unreviewed
6
Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation.
Vishwash SK, Soni RB, Kosey S, Sood R. · 2026-08-06

unreviewed
7
Comparative efficacy and safety of first-line treatments for RAS wild-type metastatic colorectal cancer: A systematic review and network meta-analysis.
Wu S, Wang C, Liu S. · 2026-06-03

open access unreviewed
8
Farnesoid X receptor and nuclear factor erythroid 2-related factor 2 synergistically ameliorate cholestatic liver injury by coordinating bile acid metabolism and transport.
Zhou L, Liu Y, Gu Q, Du X, Liu F, Liu J, Xia C. · 2026-06-08

unreviewed
9
Enhancement of ursolic acid (UA), an active ingredient in hawthorn, on the uptake and metabolism of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) derived from Polygonum multiflorum.
Li R, Ren S, Zhao Y, An N, Song J, Guan F, Ge J. · 2026-05-10

unreviewed
10
Early postoperative carbohydrate antigen 19-9 normalization drives prognosis after pancreatic ductal adenocarcinoma resection.
Elemosho A, Chatzipanagiotou OP, Angez M, Baldo A, Mevawalla A, Alizai Q, Pawlik TM. · 2026-05-21

unreviewed

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