Bilirubin UDP-glucuronosyltransferase (UGT1A1)
Cofactors used
Clinical / pharmacological. Gilbert syndrome (mild), Crigler-Najjar types I and II
What it does, reaction by reaction
Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut
Bilirubin + 2 UDP-glucuronic acid → bilirubin mono- and predominantly diglucuronide + 2 UDP
Converts Bilirubin UDP-glucuronate into Bilirubin diglucuronide UDP
› Notes
Endoplasmic-reticulum bilirubin UDP-glucuronosyltransferase (UGT1A1) conjugates the two propionic-acid side chains using UDP-glucuronic acid. This is the rate-limiting enzymatic step of hepatic bilirubin clearance and produces water-soluble conjugated bilirubin; bilirubin diglucuronide is then actively secreted into bile by the ATP-dependent canalicular transporter MRP2 (ABCC2).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
2
Spatiotemporal synergistic drug co-delivery via a dual-crosslinked liposomal platform for potent NETs blockade in rheumatoid arthritis.
Wang Q, Ren J, Wen X, Hua Y, Liao Z, Weng Y, Cai F, Qin X, Zeng Y. · 2026-08-24
unreviewed -
3
Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP.
Akhtar N, Barnes J, Gardiner P, Gurley BJ, Ko R, Koturbash I, Patel D, van Breemen RB, Roe AL. · 2026-06-27
cited 1× open access unreviewed -
4
Digeda-8 formula attenuates cholestatic liver injury in rats by restoring bile acid transport and suppressing inflammation: An integrated metabolomics and proteomics approach.
Bayoude A, Yi R, Zhao Y, Runa A, Ming M, Hu S, Jirimu B. · 2026-06-24
unreviewed -
5
<b>Gut bacterial</b> <i><b>O</b></i><b>-demethylation modulates systemic exposure to oral etoposide</b>.
Tripathi A, Kyawt TE, Shin J, Won KJ, Armstrong AT, Ilktach G, Sullivan P, Weilbaker HA, Ko Y, Lee S, Lee W, … · 2026-02-13
cited 3× open access unreviewed -
6
Assessment of reproductive risks of bisphenol S in male BALB/c mice through functional histological and multi-omics investigations.
Lin X, Liu H, Ma W, Lu S, Li B, Zhang W, Li N, Chen T. · 2026-08-18
unreviewed -
7
Association of UGT and CYP genotype-predicted activity with tyrosine kinase inhibitor toxicity.
Moy AT, D'Angelo LE, Hertz DL. · 2026-07-28
unreviewed -
8
DPYD and UGT1A1 Genotype-Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant-Specific Impact on Treatment Intensity and Toxicity.
Gambron M, Peruzzi E, Perfler S, Montico M, Cecchin R, De Mattia E, Spina M, Lisanti C, Corsetti S, Foltran L… · 2026-06-09
open access unreviewed -
9
Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center
Moorthy G, Sereika A, Kaul K, Parilla M, Alikhan M, Bouma M, Wake D, Hulick P, Dunnenberger H, Sabatini L, Ya… · 2026-10-01
open access unreviewed -
10
Low Phospholipid-Associated Cholelithiasis in a Mother-Son Pair Associated With a Novel <i>ABCB4</i> Frameshift Variant.
Yang HM, Liu J, Zhang Z. · 2026-10-02
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.