Bilirubin UDP-glucuronosyltransferase (UGT1A1)
Cofactors used
Clinical / pharmacological. Gilbert syndrome (mild), Crigler-Najjar types I and II
What it does, reaction by reaction
Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut
Bilirubin + 2 UDP-glucuronic acid → bilirubin mono- and predominantly diglucuronide + 2 UDP
Converts Bilirubin UDP-glucuronate into Bilirubin diglucuronide UDP
› Notes
Endoplasmic-reticulum bilirubin UDP-glucuronosyltransferase (UGT1A1) conjugates the two propionic-acid side chains using UDP-glucuronic acid. This is the rate-limiting enzymatic step of hepatic bilirubin clearance and produces water-soluble conjugated bilirubin; bilirubin diglucuronide is then actively secreted into bile by the ATP-dependent canalicular transporter MRP2 (ABCC2).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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