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unreviewed

Beta-ureidopropionase

2 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

2 reactions

Pyrimidine Degradation Nucleotide Metabolism · Cytosol

step 10 Irreversible/directional

N-Carbamyl-beta-alanine → beta-alanine

Converts N-Carbamyl-beta-alanine into beta-Alanine

› Notes

Beta-ureidopropionase catalyzes N-carbamyl-beta-alanine + H2O → beta-alanine + NH3 + CO2. This completes the uracil-derived ring-carbon/nitrogen disposal sequence.

step 11 Irreversible/directional

N-Carbamyl-beta-aminoisobutyrate → beta-aminoisobutyrate

Converts N-Carbamyl-beta-aminoisobutyrate into beta-Aminoisobutyrate

› Notes

Beta-ureidopropionase catalyzes N-carbamyl-beta-aminoisobutyrate + H2O → beta-aminoisobutyrate + NH3 + CO2.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pyrimidine Degradation

Accelerated by

N-carbamyl-beta-amino acid availability

Inhibited by

Product effects; inherited loss of function

Hormonal control

No established direct hormonal control.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Pan-cancer characterization of the pyrimidine catabolic enzyme UPB1 identifies a tumor-suppressive prognostic biomarker in skin cutaneous melanoma.

    Men Y, Shao Y, Chen Y, Wang P, Li Y, Yang Z, Feng R, Wang H, Song Y, Ding C. · 2026-07-16

    unreviewed
  2. 2
    Blocking β-alanine synthesis triggers widespread perturbations of energy and lipid metabolism in the brain.

    Homaei SC, Mahootchi E, Srivastava A, Gomladu MS, Krokengen OC, Baumann A, Haavik J. · 2026-05-23

    open access unreviewed
  3. 3
    Pharmacokinetics of 5-Fluorouracil in Patients Treated With Capecitabine Carrying the c.1236G>A <i>DPYD</i> Variant Allele.

    Heersche N, Knikman JE, Deenen MJ, Rosing H, van Schaik RHN, Beijnen JH, Schellens JHM, Gelderblom H, Guchela… · 2026-06-08

    open access unreviewed
  4. 4
    Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.

    Terra C, Terrier O, Le Gouellec A. · 2026-06-02

    open access unreviewed
  5. 5
    Candidate Cyanide Resistance Genes in Eutardigrade (Tardigrada) Genomes and KCN Resistance of <i>Hypsibius exemplaris</i>.

    Bartylak T, Mioduchowska M, Kmita H, Kaczmarek Ł. · 2026-05-29

    open access unreviewed
  6. 6
    Nonlinear kernel-based high-dimensional inference for set-based genetic association studies.

    Zhang Z, Yang H, Zhu M, Guo R, Chen F, Dong H, Cui Y, Yang H. · 2026-05-01

    open access unreviewed
  7. 7
    Single-cell transcriptomics reveals lateral transfers of multiple functional genes from prokaryotes to free-living ciliated protists in detrital food webs.

    Zhang Q, Gentekaki E, Leger MM, Zou S, Zhang GA, Omar A, Fu Y, Gong J. · 2026-05-15

    cited 1× open access unreviewed
  8. 8
    Pharmacokinetic and pharmacogenomic profile of capecitabine and oxaliplatin in a patient with gastric cancer undergoing hemodialysis: a case report.

    Nakano Y, Hirai T, Nishijo N, Uematsu Y, Nakajima Y, Ozaki T, Shibata R, Imada A, Naritomi K, Ogata F, Kawasa… · 2026-05-13

    unreviewed
  9. 9
    β-ureidopropionase deficiency mimicking Leigh syndrome associated with methylmalonic aciduria.

    Ferrera G, Boenzi S, Lamantea E, Ghezzi D, Ardissone A. · 2026-05-04

    unreviewed
  10. 10
    Sodium butyrate suppresses endometrial cancer cell growth by inhibiting thymidylate synthase and reprogramming pyrimidine metabolism.

    Kim N, Park S, Yang C. · 2026-05-02

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.