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unreviewed

Asparaginase

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix

step 3 Irreversible

L-asparagine + H₂O → L-aspartate + NH₄⁺

Converts Asparagine H2O into Aspartate NH4+

› Notes

Asparaginase catalyzes irreversible deamidation, providing a smaller additional source of ammonia. The resulting aspartate can be transaminated to oxaloacetate and glutamate or can donate nitrogen to the urea cycle.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    scYeast: a biological-knowledge-guided foundation model on yeast single-cell transcriptomics.

    Fan X, Liao W, Xiao L, Yan X, Lu H. · 2026-07-16

    open access unreviewed
  2. 2
    Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.

    Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28

    open access unreviewed
  3. 3
    Epidemiology and outcomes of invasive fungal infections in patients with mature T-cell and NK-cell lymphomas.

    Tsai MT, Chen PY, Huang TC, Wang JT, Chou WC, Chen YC. · 2026-08-26

    open access unreviewed
  4. 4
    Economic burden associated with switching from frontline pegaspargase or calaspargase pegol to second-line recombinant <i>Erwinia</i> in pediatrics and adolescents/young adults with acute lymphoblastic leukemia.

    McCormick M, Gu T, Bhagnani T, Prashar A, Chatterjee I, Papademetriou E, Maese L. · 2026-05-21

    unreviewed
  5. 5
    Remodeling memory T cells with chemotherapy and immune checkpoint inhibitors as host pre-conditioning to empower in vivo CAR-T therapy.

    Sun DY, Wang JL, Li X, Wang S. · 2026-04-27

    open access unreviewed
  6. 6
    The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.

    Kim J, Lee JH, Hwang SH, Choi JH, Won YW, Hur JY. · 2026-02-24

    open access unreviewed
  7. 7
    Acute leukemia during pregnancy: a single center experience with 23 cases, 2012-2022 and literature review.

    Liu W, Guo J, Gai D, Zhang KX, Liu Y, Zhao XL, Fu X, Rosen ST, Chen C, Chen F. · 2026-02-18

    open access unreviewed
  8. 8
    Palbociclib in combination with dexamethasone, bortezomib, and doxorubicin for pediatric relapsed acute lymphoblastic leukemia.

    Srinivasan SG, Kamens JL, Marks LJ, Balagtas JMS, Rubnitz JE, Gruber TA. · 2026-07-25

    open access unreviewed
  9. 9
    Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.

    Li M, Huang C, Yu S. · 2026-07-02

    open access unreviewed
  10. 10
    Safety evaluation of the food enzyme containing endo‐polygalacturonase, pectinesterase, pectin lyase and arabinan endo‐1,5‐α‐l‐arabinanase activities from the non‐genetically modified Aspergillus sp. strain ASNSC

    · 2026-10-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.