What it does, reaction by reaction
Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix
L-asparagine + H₂O → L-aspartate + NH₄⁺
Converts Asparagine H2O into Aspartate NH4+
› Notes
Asparaginase catalyzes irreversible deamidation, providing a smaller additional source of ammonia. The resulting aspartate can be transaminated to oxaloacetate and glutamate or can donate nitrogen to the urea cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Economic burden associated with switching from frontline pegaspargase or calaspargase pegol to second-line recombinant <i>Erwinia</i> in pediatrics and adolescents/young adults with acute lymphoblastic leukemia.
McCormick M, Gu T, Bhagnani T, Prashar A, Chatterjee I, Papademetriou E, Maese L. · 2026-05-21
unreviewed -
2
Remodeling memory T cells with chemotherapy and immune checkpoint inhibitors as host pre-conditioning to empower in vivo CAR-T therapy.
Sun DY, Wang JL, Li X, Wang S. · 2026-04-27
open access unreviewed -
3
The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.
Kim J, Lee JH, Hwang SH, Choi JH, Won YW, Hur JY. · 2026-02-24
open access unreviewed -
4
Acute leukemia during pregnancy: a single center experience with 23 cases, 2012-2022 and literature review.
Liu W, Guo J, Gai D, Zhang KX, Liu Y, Zhao XL, Fu X, Rosen ST, Chen C, Chen F. · 2026-02-18
open access unreviewed -
5
Genetic Determinants of Treatment-Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia.
Abaji R, Gagné V, Espagne É, Alos N, Del Vecchio V, Ait Said L, Shalmiev A, Fuchs C, Laverdière C, Leclerc JM… · 2026-06-22
unreviewed -
6
Ferroptosis and prostate cancer: A translational path from molecular mechanisms to precision therapy.
Huang Y, Ma Y, He J, Song T. · 2025-12-08
open access unreviewed -
7
Extranodal Natural Killer/T-Cell Lymphoma Mimicking Chronic Mucormycosis.
Yun J, Lin ME, Madrigal J, Tyagi R, Ni G, Chia JJ, Kang R. · 2026-04-07
unreviewed -
8
Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings-international expert consensus.
DeAngelo DJ, Avagyan A, Alfaro J, Conter V, de Martino Lee ML, Hutnik Ł, Hwang M, Inaba H, Manabe A, Park JH,… · 2026-08-01
unreviewed -
9
Pegaspargase Rechallenge Following Grade 2 Hypersensitivity Reaction in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 16-001.
Burns MA, Flamand Y, Keating J, Koch V, Cronholm SM, Hunt SK, Cole PD, Gennarini LM, Hijiya N, Kahn JM, Kelly… · 2026-08-11
unreviewed -
10
Optimising Asparaginase Use and Managing Hypersensitivity in Australasia-A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group.
O'Connor MJ, Martin M, Trinder SM, Barbaric D, Hanna D, Lai CY, Osborn MP, Prestige T, Ross B, Super L, Walwy… · 2026-08-10
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.