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unreviewed

Arginase I (ARG1)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Argininaemia: spastic diplegia, less severe hyperammonaemia

What it does, reaction by reaction

1 reactions

Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol

step 5 Irreversible

L-arginine + H₂O → L-ornithine + urea

Converts Arginine H2O into Ornithine Urea

› Notes

Cytosolic arginase I (ARG1), a manganese-containing enzyme, hydrolyzes arginine to urea and ornithine. This essentially irreversible final step regenerates ornithine for mitochondrial import and releases urea into blood for renal excretion.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Urea Cycle

Listed there as: Arginase I

Accelerated by

Arginine availability; manganese

Inhibited by

Product accumulation; severe hepatic dysfunction

Hormonal control

Long-term expression rises with increased amino-acid catabolism; predominantly indirect hormonal control

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis.

    Viola H, Carter H, Griffin K, Costa RM, McDonald R, Callow B, Gonzalez de Los Santos F, Panovich P, Carey S, … · 2026-06-19

    unreviewed
  2. 2
    Tumor-educated macrophages promote cytokine-driven lung colonization in triple-negative breast cancer.

    Rosado-Sanz M, Martínez-Alarcón N, Meel MH, Rius-Perez S, Tolboom ZJ, Salvador-Coloma C, Burgos-Panadero R, C… · 2026-06-19

    open access unreviewed
  3. 3
    Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics.

    Lang M, Feng Y, Zhou L, Li B, Li W, Zhao J, Chen K, Li L, Qiu L, Qian Z, Zhou S, Zhang H, Chu Z. · 2026-06-05

    open access unreviewed
  4. 4
    Dectin-1 signaling promotes Galectin-3 shedding and expansion of immunosuppressive CD71+ erythroid cells in breast cancer.

    Azimi A, Rahmati A, Shahbaz S, Elahi Z, Zahiriabyaneh A, Cao J, Padua EL, Church C, Alimo ET, Lavasanifar A, … · 2026-06-02

    open access unreviewed
  5. 5
    Combining bioinformatics and machine learning to analyze and validate sepsis-related cell senescence genes and potential drugs.

    Pei S, Li D, Yu X, Huang X, Liu J, Song Y, Zhu L, Cui J, Cui Y, Xie K. · 2026-05-31

    open access unreviewed
  6. 6
    The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors.

    Ding JB, Lin MX, Zang D, Chen J. · 2026-05-28

    open access unreviewed
  7. 7
    Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives.

    Zainuddin MS, Pamidi N, Azman AS, Bai Magalingam K, Bhuvanendran S. · 2026-05-26

    open access unreviewed
  8. 8
    The "oral-gut axis" transmission of microorganisms in colorectal cancer: Insights from <i>Peptostreptococcus'</i> perspective.

    Zhu Y, Luo S, Luo Y, Guo Z, Jiang Y, Ma Q, Fu X, Zheng C, You F, Kuang Q, Li X. · 2026-05-26

    open access unreviewed
  9. 9
    Thyroid cancer-derived exosomal SPP1 promotes tumor progression by driving macrophage M2 polarization through the CD44/JAK2/STAT3 signaling pathway.

    Yang J, Yin W, Ge J, Gao G, Yao X, Huang Y. · 2026-05-19

    open access unreviewed
  10. 10
    Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy.

    Shafaghat Z, Golshanrad P, Saharkhiz S, Leśniak A, Mikeladze D, Datukishvili N, Ramezani Farani M, Alipourfar… · 2026-05-18

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.