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unreviewed

Arginase I (ARG1)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Argininaemia: spastic diplegia, less severe hyperammonaemia

What it does, reaction by reaction

1 reactions

Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol

step 5 Irreversible

L-arginine + H₂O → L-ornithine + urea

Converts Arginine H2O into Ornithine Urea

› Notes

Cytosolic arginase I (ARG1), a manganese-containing enzyme, hydrolyzes arginine to urea and ornithine. This essentially irreversible final step regenerates ornithine for mitochondrial import and releases urea into blood for renal excretion.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Urea Cycle

Listed there as: Arginase I

Accelerated by

Arginine availability; manganese

Inhibited by

Product accumulation; severe hepatic dysfunction

Hormonal control

Long-term expression rises with increased amino-acid catabolism; predominantly indirect hormonal control

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.

    Yang D, Zheng Z, Wang H, Zhao H, Li Z, Liu Y, Xiong Y, Luo Z. · 2026-09-08

    open access unreviewed
  2. 2
    Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.

    Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03

    open access unreviewed
  3. 3
    Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment.

    Saxton SH, Kang I, Mitchell S, Lotto J, Upadhyay A, Zou C, Quirk C, McCray TN, Prado O, Johansson F, Fortin C… · 2026-07-23

    open access unreviewed
  4. 4
    Nanoadjuvant-based membrane poration boosts antitumor immunity via modulating mitochondrial metabolism to downregulate PD-L1 and upregulate STING.

    You W, Gao F, Wang HL, Shen AZ, Zhang Z, Nie X, Huang WQ, Wang LH, You YZ. · 2026-09-11

    open access unreviewed
  5. 5
    Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.

    Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28

    open access unreviewed
  6. 6
    BMP-2-driven osteo-organoid formation retains key osteogenic-support features and promotes bone repair following total-body irradiation.

    Zhu F, Ji L, Wang J, Liu C. · 2026-08-27

    open access unreviewed
  7. 7
    Interpretable AI-driven materiomics to decode microenvironmental cues for stem cell immunomodulation.

    Pan C, He Y, Duan Y, Chen K, Wang Q, Wang X, Zhang Y, An C, Wang H. · 2026-08-13

    open access unreviewed
  8. 8
    Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.

    Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, F… · 2026-08-14

    open access unreviewed
  9. 9
    A hierarchical, pH-responsive nanocomposite hydrogel platform for synergistic microenvironment reprogramming and attenuation of inflammatory periodontal bone loss.

    Zhang Y, Jing X, Wang X, Zhang Z, Xin J, Chang Z, Su Y, Yan Z, Lu A, Lu H. · 2026-08-04

    open access unreviewed
  10. 10
    Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs.

    Zhao S, Chen L, Shao Z, Sun Y, Mu X, Yao M, Chen J, Jin X, Wang F, Chai X, Xue Y, Yinwang E, Chen S, Mou H, W… · 2026-08-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.