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unreviewed

Adipose triglyceride lipase (ATGL; PNPLA2)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. First and rate-limiting step of adipocyte lipolysis

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 8 Irreversible/directional

TAG + H2O → DAG + free fatty acid

Converts Triacylglycerol (TAG) H2O into Diacylglycerol Fatty acid

› Notes

During lipolysis, adipose triglyceride lipase (ATGL; PNPLA2) catalyzes the first and often rate-setting TAG hydrolysis. Its activity is strongly enhanced by CGI-58/ABHD5 released from phosphorylated perilipin, and is restrained by G0S2.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.

    Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03

    open access unreviewed
  2. 2
    Strength training induces ABHD5-ATGL axis to counteract mesenteric fat accumulation in obese Swiss mice.

    de Melo DG, Ramos CO, da Cruz Rodrigues VC, de Sá Pereira GJ, Dos Santos Brícola R, Cintra DEC, de Moura LP. · 2026-06-23

    unreviewed
  3. 3
    Ambra1 is essential for fasting-induced lipolysis via ATGL translocation to lipid droplets.

    Kashikawa T, Akatsuka H, Suzuki T, Hosokawa H, Yamamoto N, Hozumi K, Sato T. · 2026-06-19

    unreviewed
  4. 4
    Single-cell analysis revealed potential mechanisms of biomarkers related to polyamine metabolism in osteoarthritis.

    Zhang K, Zhang Y, Chen S, Liu Z, Yang W, Yu Y, Lv Z, Feng Y, Zhang Y. · 2026-06-04

    unreviewed
  5. 5
    A Cross-Species Single-Cell Transcriptomic Atlas of Subcutaneous Adipose Tissue Reveals Conserved and Divergent Cellular Programs.

    Niu X, Zhai L, Wang L, Wang J, Zheng Z, Yang J, Wang X, Liu J, Xing K, Wang C. · 2026-08-01

    unreviewed
  6. 6
    Comprehensive metabolic characterization of pediatric ependymomas.

    Li T, Jin Y, Ren S, Liu Y, Cheng D, Bi Z, Li Y, Chen X, Zhu X, Chen Z, He W, Li Y, Liu Y, Luan G, Tian Y, Liu… · 2026-04-20

    open access unreviewed
  7. 7
    The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis.

    Yang Y, Zhu X, Fang Y, Li J, Shao X, Li S, Jin H, Qi C, Li Z, Gu L, Mou S, Lin Q, Ni Z. · 2026-05-05

    unreviewed
  8. 8
    HILPDA Repression Induces Methuosis in Breast and Liver Cancer Cells by Dysregulating Lipid Metabolism.

    Wang J, Zhai C, Zhang C, Fan A, Jalal S, Zhang T, Xu T, Gao C, Chen X, Teng H, Luo Y, Li C, Huang L. · 2026-07-01

    unreviewed
  9. 9
    Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.

    Xie S, Chen K, Sun X, Ye Y, Chen R, Jiang C, Chen M, Lv X, Li H, Liao Y, Chen W, Deng L, Cai L, Liang Y, Wei … · 2026-07-30

    unreviewed
  10. 10
    Comparative Transcriptomics of Feather Follicles Reveals Potential Candidate Genes for Duck Feather Type Differentiation.

    Wang W, Guo J, Wang L, Zhang M, Zhang X, Jiang X, Chen T, Mei X, Ren X, Qu L. · 2026-07-22

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.