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unreviewed

Adipose triglyceride lipase (ATGL; PNPLA2)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. First and rate-limiting step of adipocyte lipolysis

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 8 Irreversible/directional

TAG + H2O → DAG + free fatty acid

Converts Triacylglycerol (TAG) H2O into Diacylglycerol Fatty acid

› Notes

During lipolysis, adipose triglyceride lipase (ATGL; PNPLA2) catalyzes the first and often rate-setting TAG hydrolysis. Its activity is strongly enhanced by CGI-58/ABHD5 released from phosphorylated perilipin, and is restrained by G0S2.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Triacylglycerol metabolism is a novel target to combat West Nile virus infection.

    Caridi F, Mingo-Casas P, Esteban A, Poderoso T, de Oya NJ, Calvo-Pinilla E, Zhang B, Priego EM, Pérez-Pérez M… · 2026-09-18

    open access unreviewed
  2. 2
    Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.

    Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03

    cited 1× open access unreviewed
  3. 3
    Targeting the Snail1-ATGL-ferroptosis-EMT axis via AKT-GSK3β signaling: Low-dose colchicine attenuates idiopathic pulmonary fibrosis.

    Shi L, Zhan S, Wang X, Han S, Lu S, Li R, Xie J, Yang C, Adili M, Zhang H, Hong JS, Wang Y, Feng J. · 2026-09-24

    unreviewed
  4. 4
    Lipophagy: A key regulator in oxidative stress and metabolic disorders.

    Zhao Q, Qu F, Jin Y. · 2026-01-22

    cited 1× open access unreviewed
  5. 5
    Lipid dysregulation in mouse ovarian antral follicles after oral exposure to a human relevant mixture of three phthalates.

    Miller KL, Massey T, Metzler V, Adams A, Liu X, Burns K, Porter LR, Snider J, Craig ZR. · 2026-06-06

    cited 3× unreviewed
  6. 6
    Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis.

    Li G, Wang Y, Wang W, Liu T, Obeng E, Li S. · 2025-12-11

    open access unreviewed
  7. 7
    ALS/FTD-linked TDP-43 alterations prevent HSV-1 infection by disrupting cell-adhesion pathways

    · 2026-10-02

    open access unreviewed
  8. 8
    Cyp27b1 Deficiency Impairs Ovarian Development Through Disrupted 1,25(OH)<sub>2</sub>D<sub>3</sub> Regulation of Lipid Metabolism and Redox Homeostasis.

    Yang G, Zhang Y, Huang Y, Bayir A, Wang C. · 2026-10-01

    unreviewed
  9. 9
    Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

    Machado J, Karthikaisamy V, Mohr H, Kaltenecker D, Benedikt P, Morigny P, Mhamane A, Geppert J, Fumo AR, Haas… · 2026-10-01

    open access unreviewed
  10. 10
    Recent advances in adult-onset disorders of muscle lipid metabolism.

    Liewluck T, Laforêt P. · 2026-09-03

    cited 1× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.