Adipose triglyceride lipase (ATGL; PNPLA2)
Cofactors used
Clinical / pharmacological. First and rate-limiting step of adipocyte lipolysis
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
TAG + H2O → DAG + free fatty acid
Converts Triacylglycerol (TAG) H2O into Diacylglycerol Fatty acid
› Notes
During lipolysis, adipose triglyceride lipase (ATGL; PNPLA2) catalyzes the first and often rate-setting TAG hydrolysis. Its activity is strongly enhanced by CGI-58/ABHD5 released from phosphorylated perilipin, and is restrained by G0S2.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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