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rate-limiting unreviewed

Adenylosuccinate synthetase

1 reactions · 1 pathways

Cofactors used

GTP Pi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 12 Irreversible/directional

IMP → adenylosuccinate

Converts IMP into Adenylosuccinate

› Notes

Adenylosuccinate synthetase catalyzes IMP + aspartate + GTP → adenylosuccinate + GDP + Pi. GTP, rather than ATP, drives addition of the amino group donor aspartate; this reciprocal use of GTP favors balanced AMP/GMP production. This is the committed step of the AMP branch.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Accelerated by

Increased IMP and GTP availability

Inhibited by

AMP (feedback inhibition)

Hormonal control

Predominantly governed by energy status and substrate balance rather than acute hormonal regulation.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis.

    Singh V, Zhang R, Chen K, Li Z, Li H. · 2026-07-31

    unreviewed
  2. 2
    Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics.

    He X, Zhang L, Li Y, Liu SB, Li Z, Dong H, Baker GE, Nguyen LXT, Chen W, Wang J, Jia Z, Lu X, Lin YC, Hu Z, Y… · 2026-06-26

    unreviewed
  3. 3
    Beyond Urease: New Potential Enzymatic Targets in <i>Helicobacter pylori</i>.

    Camini AM, Cogo LR, Delawi ME, Anton DB, Koakovski Acosta J, de Lima JC, Saraiva Macedo Timmers LF. · 2026-06-04

    open access unreviewed
  4. 4
    Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.

    Terra C, Terrier O, Le Gouellec A. · 2026-06-02

    open access unreviewed
  5. 5
    Profiling of genetic determinants required for fitness of community-associated methicillin-resistant <i>Staphylococcus aureus</i> in human blood.

    Abdelmalek N, Yousief SW, Bojer MS, Olsen JE, Rubino S, Paglietti B. · 2026-04-21

    open access unreviewed
  6. 6
    Structural diversity of lipid A modulates neutrophil proteome and secretome responses.

    Pittaluga Villarreal JR, Kim D, Yoon SH, Bhushan V, Issara-Amphorn J, Pederson J, Manes NP, Nita-Lazar A. · 2026-03-10

    cited 1× unreviewed
  7. 7
    Automated high-throughput microscopy screening unveiled new Listeria monocytogenes genes involved in cell infection.

    Alves Â, Meireles D, Suriano C, Monteiro R, Oliveira R, Bernardes BG, Sousa S, Pombinho R, Cabanes D. · 2026-01-13

    cited 1× unreviewed
  8. 8
    Genome-wide analysis exploring mechanisms used by <i>Shigella sonnei</i> to survive long-term nutrient starvation.

    Matanza XM, Leung PB, Torraca V, Watson J, Dorman MJ, Thomson NR, Clements A. · 2026-03-16

    open access unreviewed
  9. 9
    Genetic Diagnosis and Discovery Enabled by Large Language Models.

    Tu T, Saab K, Liu W, Fang Z, Cheng Z, Spasic S, Djurisic M, Mohri H, Ren W, Palepu A, Gottweis J, Karthikesal… · 2026-02-08

    open access unreviewed
  10. 10
    IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review).

    Zhu H, Wang H, Li X, Zhang W, Wang Y, Tan Q, Ying D, Shi Z, Song J. · 2026-02-06

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.