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rate-limiting unreviewed

Adenylosuccinate synthetase

1 reactions · 1 pathways

Cofactors used

GTP Pi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 12 Irreversible/directional

IMP → adenylosuccinate

Converts IMP into Adenylosuccinate

› Notes

Adenylosuccinate synthetase catalyzes IMP + aspartate + GTP → adenylosuccinate + GDP + Pi. GTP, rather than ATP, drives addition of the amino group donor aspartate; this reciprocal use of GTP favors balanced AMP/GMP production. This is the committed step of the AMP branch.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Accelerated by

Increased IMP and GTP availability

Inhibited by

AMP (feedback inhibition)

Hormonal control

Predominantly governed by energy status and substrate balance rather than acute hormonal regulation.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast <i>Rhodotorula toruloides</i>.

    Chen Q, Lyu L, Wang S, Zhao ZK. · 2026-08-06

    open access unreviewed
  2. 2
    Breed-specific meat quality and flavor characteristics of Wannan and Chinese Simmental cattle revealed by whole transcriptome and metabolome analysis.

    Song N, Wang J, Meng X, Cui S, Jin S, Tang H, Zhang Y, Liu H. · 2026-09-01

    open access unreviewed
  3. 3
    Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis.

    Singh V, Zhang R, Chen K, Li Z, Li H. · 2026-07-31

    unreviewed
  4. 4
    Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus.

    Winzey KD, Guzman S, Yang E, Moreira D, Wang X, Gu X, Dillon ST, Ely EW, Karumanchi SA, Libermann TA, Lahiri … · 2026-09-29

    open access unreviewed
  5. 5
    Mitochondrial Fitness as a Functional Immune Checkpoint in Cancer: Metabolic Plasticity, Tumor Evolution, and Immunotherapy.

    Morabito F, Martino EA, Bruzzese A, Amodio N, Vigna E, Gentile M. · 2026-09-01

    open access unreviewed
  6. 6
    Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies.

    Zhang J, Liu J, Zhao M, Zhang X, Liu L, Li M, Cao C, Zhang R, Zhao M. · 2026-09-01

    open access unreviewed
  7. 7
    Effects of florfenicol on linezolid resistance in Enterococcus faecium from waterfowl farms.

    Zhang S, Hu Z, Yang J, Wang M, Liu M, Zhu D, Zhao X, Wu Z, Cheng A. · 2026-08-20

    open access unreviewed
  8. 8
    Catfish Transgenesis and Gene Editing: Overview, Recent Advances, and Future Perspectives.

    Elaswad AH, Khalil KM, Dunham RA. · 2026-08-11

    open access unreviewed
  9. 9
    Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery.

    Olayinka O, Farrell JJ, Zhu C, Khurshid Z, Alzheimer's Disease Sequencing Project, Martin ER, Bush WS, Perica… · 2026-08-01

    cited 1× open access unreviewed
  10. 10
    Development of ganciclovir as an anti-human cytomegalovirus drug: historical perspectives and future prospects.

    Garcia Del Valle N, Strang BL. · 2026-08-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.