What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
IMP → adenylosuccinate
Converts IMP into Adenylosuccinate
› Notes
Adenylosuccinate synthetase catalyzes IMP + aspartate + GTP → adenylosuccinate + GDP + Pi. GTP, rather than ATP, drives addition of the amino group donor aspartate; this reciprocal use of GTP favors balanced AMP/GMP production. This is the committed step of the AMP branch.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)
Increased IMP and GTP availability
AMP (feedback inhibition)
Predominantly governed by energy status and substrate balance rather than acute hormonal regulation.
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