unreviewed

Adenosine deaminase (ADA)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. ADA deficiency: severe combined immunodeficiency (dATP accumulation inhibits RNR)

What it does, reaction by reaction

1 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 3 Irreversible/directional

Adenosine → inosine

Converts Adenosine into Inosine

› Notes

Adenosine deaminase (ADA) catalyzes adenosine + H2O → inosine + NH3. The enzyme requires no external redox cofactor and channels adenosine toward hypoxanthine production.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine Degradation (to Uric Acid)

Listed there as: Adenosine deaminase

Accelerated by

Adenosine availability

Inhibited by

No major physiologic small-molecule allosteric inhibitor

Hormonal control

No established direct hormonal regulation.

Recent literature

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